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自我药疗在疼痛管理中的应用:药师在优化非处方止痛药物使用方面的最新进展。

Self-medication in pain management: The state of the art of pharmacists' role for optimal Over-The-Counter analgesic use.

机构信息

Pain Center, Cochin Hospital, Paris, France.

Department of General Medicine, Paris-Est University, Créteil, France.

出版信息

Eur J Pain. 2019 Nov;23(10):1747-1762. doi: 10.1002/ejp.1459. Epub 2019 Aug 7.

Abstract

BACKGROUND AND OBJECTIVE

Self-medication is associated with an important utilization of Over-The-Counter (OTC) analgesics. The medical outcome resulting from therapeutic options bypassing the physician prescription is a major issue. In that context, pharmacists are expected to play a crucial role. The main objective of this review was to analyse the state-of-the art of pharmacists' role in pain management self-medication.

DATABASES AND DATA TREATMENT

An expert multidisciplinary group dedicated to self-medication in pain was established. Selection of publications was performed from PubMedand EMBASE databases which was based on the use of "pain" and/or "self-medication" and/or "self-care" and/or "analgesics" and/or "painkillers" keywords, restricted to the past 10 years.

RESULTS

A total of 480 papers were identified, 49 of which papers were considered relevant and finally kept for final discussion, on OTC pain management and pharmacist's role. Literature analysis demonstrates that OTC analgesics are generally safe when appropriately used. Risks associated with misuse or inappropriateness depend on patients' vulnerability (elderly, pregnancy) or behaviour. Social cognitive theory-based intervention and multimedia applications improve self-medication but do not replace health care professional advice Pharmacists' interventions may improve the benefits and safety of OTC analgesic medication, with a better management of pain.

CONCLUSIONS

Considering the heterogeneity of patients' knowledge and behaviour reported worldwide, inappropriate use of OTC pain medication should not be underestimated. Community pharmacists are ideally placed to guide self-medication or recommend a medical advice when needed. Embedding pharmacists in primary care pain management is essential and pharmacist-led medication coupled with an appropriate training of pharmacy staffs should be encouraged.

SIGNIFICANCE

Analgesics are widely used without prescription, all over the world. They represent the largest market of OTC drugs, with an overall benefit/risk ratio favourable when appropriately used. Because of potential individual risks associated to the ailment or to the patient's behaviour, pharmacists' interventions have proven to optimize analgesic self-medication, provided that pharmacy staffs are both available and more specifically trained. In the future, in pain management, especially self-medication, pharmacists should play an increasing role and should be included in educational programmes and pain management guidelines.

摘要

背景与目的

自我用药与非处方(OTC)镇痛药的大量使用密切相关。绕过医生处方选择治疗方案所带来的医疗后果是一个主要问题。在这种情况下,药剂师预计将发挥关键作用。本综述的主要目的是分析药剂师在疼痛管理自我用药中的作用现状。

数据库和数据处理

成立了一个专门研究疼痛自我用药的多学科专家小组。从 PubMed 和 EMBASE 数据库中选择出版物,使用“疼痛”和/或“自我用药”和/或“自我护理”和/或“镇痛药”和/或“止痛药”等关键词进行限制,仅检索过去 10 年的内容。

结果

共确定了 480 篇论文,其中 49 篇论文被认为与 OTC 疼痛管理和药剂师的作用相关,并最终保留进行最终讨论。文献分析表明,OTC 镇痛药在合理使用时通常是安全的。误用或不适当使用的风险取决于患者的脆弱性(老年人、孕妇)或行为。基于社会认知理论的干预和多媒体应用程序可以改善自我用药,但不能替代医疗保健专业人员的建议。药剂师的干预措施可以改善 OTC 镇痛药的获益和安全性,更好地管理疼痛。

结论

考虑到全球范围内患者知识和行为的异质性,不应低估 OTC 疼痛药物的不当使用。社区药剂师是指导自我用药或在需要时建议医疗咨询的理想人选。将药剂师纳入初级保健疼痛管理中至关重要,应鼓励以药剂师为主导的药物治疗,并对药剂师工作人员进行适当培训。

意义

镇痛药在全球范围内广泛未经处方使用。它们是 OTC 药物中最大的市场,在合理使用时具有有利的获益/风险比。由于与疾病或患者行为相关的潜在个体风险,药剂师的干预已被证明可以优化镇痛药的自我用药,前提是药剂师人员不仅可用,而且经过专门培训。在未来,在疼痛管理中,特别是在自我用药方面,药剂师应发挥越来越大的作用,并应纳入教育计划和疼痛管理指南。

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