NMIMS, School of Pharmacy and Technology Management, Shirpur, Maharashtra, India.
NMIMS, School of Pharmacy and Technology Management, Shirpur, Maharashtra, India.
Mater Sci Eng C Mater Biol Appl. 2019 Oct;103:109717. doi: 10.1016/j.msec.2019.05.002. Epub 2019 May 3.
In the twenty-first century, microneedles based drug delivery is drawing attention worldwide in the research due to current signs of progress in the controlled release drug delivery through microneedles. The microneedles represent a promising technology to deliver therapeutic compounds into the skin for chronic complications like osteoporosis, diabetes, cancer and induction of immune responses from protein and DNA vaccines. However, the delivery of hydrophilic drugs and macromolecular agents are challenging. In this write up authors included the meticulous illustration of the chronological development of fabrication of microneedles with respect to an assortment of techniques, their modifications, clinical trials and regulatory perspectives period of 2000-2019. This review summarizes characterization, fabrications, biological applications and challenges. Additionally, relevant patents based on microneedle from USPTO) database are also highlighted.
在二十一世纪，基于微针的药物输送技术由于在通过微针实现药物控制释放方面取得的进展迹象，引起了全球范围内的关注。微针代表了一种有前途的技术，可以将治疗性化合物递送到皮肤中，用于治疗骨质疏松症、糖尿病、癌症等慢性并发症，并诱导蛋白质和 DNA 疫苗的免疫反应。然而，亲水药物和大分子药物的输送具有挑战性。在这篇文章中，作者详细阐述了 2000 年至 2019 年期间，各种技术、其改进、临床试验和监管视角下微针制造的时间顺序发展。这篇综述总结了微针的特点、制造、生物应用和挑战。此外，还强调了基于美国专利商标局 (USPTO) 数据库的相关专利。
