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微针在表面增强拉曼散射检测原位采样中的应用研究进展

Recent Progress on the Application of Microneedles for In Situ Sampling in Surface-Enhanced Raman Scattering Detection.

作者信息

Yang Weiqing, Chen Ying, Cheng Xingliang, Liu Shuojiang, Zhu Huiqi, Hu Yuling

机构信息

School of Chemistry, Sun Yat-sen University, Guangzhou 510060, China.

出版信息

Biosensors (Basel). 2025 Jun 1;15(6):350. doi: 10.3390/bios15060350.

DOI:10.3390/bios15060350
PMID:40558432
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12190841/
Abstract

The efficient and non-invasive collection of biological samples has become a critical challenge for the continued development of surface-enhanced Raman scattering (SERS). When integrated with minimally invasive microneedle (MN) sampling technology, SERS enhances its applicability in real-time, non-invasive molecular detection. This review focuses on the latest advances in MN-based SERS sensors. Firstly, a comprehensive summary is presented of MN types and research progress in the design and engineering of SERS-active MNs. Then, the sampling method of SERS MNs and the MN-based SERS detection mode are also described in detail. Finally, the applications of SERS MNs in fields such as disease diagnosis, drug monitoring, and food safety are highlighted. Additionally, current challenges are discussed and future development prospects are prospected with the aim of contributing to the design of MN-based SERS sensors for diverse applications.

摘要

生物样品的高效无创采集已成为表面增强拉曼散射（SERS）持续发展的一项关键挑战。当与微创微针（MN）采样技术相结合时，SERS增强了其在实时无创分子检测中的适用性。本综述聚焦于基于MN的SERS传感器的最新进展。首先，全面总结了MN的类型以及SERS活性MN设计与工程方面的研究进展。然后，还详细描述了SERS MN的采样方法以及基于MN的SERS检测模式。最后，突出了SERS MN在疾病诊断、药物监测和食品安全等领域的应用。此外，还讨论了当前面临的挑战并展望了未来的发展前景，旨在为设计用于各种应用的基于MN的SERS传感器提供帮助。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0ce/12190841/48da9d7b508a/biosensors-15-00350-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0ce/12190841/ea2c11ce5368/biosensors-15-00350-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0ce/12190841/166d3d6bf8db/biosensors-15-00350-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0ce/12190841/f431b6461cbc/biosensors-15-00350-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0ce/12190841/d9637d2a1e9b/biosensors-15-00350-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0ce/12190841/5318851e135e/biosensors-15-00350-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0ce/12190841/606d013e0b2f/biosensors-15-00350-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0ce/12190841/6c5763a89cff/biosensors-15-00350-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0ce/12190841/f52e296c5b76/biosensors-15-00350-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0ce/12190841/48da9d7b508a/biosensors-15-00350-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0ce/12190841/ea2c11ce5368/biosensors-15-00350-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0ce/12190841/166d3d6bf8db/biosensors-15-00350-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0ce/12190841/f431b6461cbc/biosensors-15-00350-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0ce/12190841/d9637d2a1e9b/biosensors-15-00350-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0ce/12190841/5318851e135e/biosensors-15-00350-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0ce/12190841/606d013e0b2f/biosensors-15-00350-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0ce/12190841/6c5763a89cff/biosensors-15-00350-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0ce/12190841/f52e296c5b76/biosensors-15-00350-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0ce/12190841/48da9d7b508a/biosensors-15-00350-g009.jpg

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引用本文的文献

[1]
Recent Developments in Microneedle Biosensors for Biomedical and Agricultural Applications.

Micromachines (Basel). 2025-8-13

本文引用的文献

[1]
Multifunctional Hydrogel Microneedles (HMNs) in Drug Delivery and Diagnostics.

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[2]
Rapid enrichment and SERS differentiation of various bacteria in skin interstitial fluid by 4-MPBA-AuNPs-functionalized hydrogel microneedles.

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[3]
Wearable SERS devices in health management: Challenges and prospects.

Spectrochim Acta A Mol Biomol Spectrosc. 2025-6-5

[4]
Advances, Challenges, and Opportunities in Plasmonic Nanogap-Enhanced Raman Scattering with Nanoparticles.

ACS Nano. 2025-1-28

[5]
Polydopamine-Mediated, Centrifugal Force-Driven Gold Nanoparticle-Deposited Microneedle SERS Sensors for Food Safety Monitoring Theoretical Study of the SERS Substrate Fabrication.

ACS Sens. 2025-1-24

[6]
Hydrogel-Forming Microneedles and Applications in Interstitial Fluid Diagnostic Devices.

Adv Healthc Mater. 2025-1

[7]
Bifunctional MoO/CuS Heterojunction Nanozyme-Driven "Turn-On" SERS Signal for the Sensitive Detection of Cerebral Infarction Biomarker S100B.

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[8]
Microorganism microneedle micro-engine depth drug delivery.

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[9]
Inkjet Printing Patterned Plasmonic SERS Platform with Surface-Optimized Paper for Label-Free Detection of Illegal Drugs in Urine.

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[10]
A Multicomponent Microneedle Patch for the Delivery of Meloxicam for Veterinary Applications.

ACS Nano. 2024-9-17

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