State Key Laboratory for Mechanical Behavior of Materials, Xi'an Jiaotong University, Xi'an 710049, China.
State Key Laboratory for Mechanical Behavior of Materials, Xi'an Jiaotong University, Xi'an 710049, China.
Mater Sci Eng C Mater Biol Appl. 2019 Oct;103:109854. doi: 10.1016/j.msec.2019.109854. Epub 2019 Jun 3.
Combination of different therapy modalities with multiple tumoricidal mechanisms has emerged as a promising anticancer strategy. Herein, we reported an aldehyde/catechol-functionalized hyaluronic acid (DAHA) and hydroxyethyl chitosan (HECS) decorated gold nanorod (GNR) platform for combined chemo-photothermal therapy of breast cancer. The DAHA was synthesized by conjugating dopamine onto oxidized hyaluronic acid. The nanoplatform was prepared by successively modifying GNR with DAHA via Au-catechol bonds, conjugating DOX onto DAHA moiety through Schiff base linkage, and coating HECS interlayer for charge-reversal and hyaluronic acid corona for tumor cell targeting. The resulting nanoplatform GNR-HACH exhibited acid-triggered surface charge-reversal and pH/NIR dual-responsive drug release behaviors. The nanoplatform could be efficiently internalized into MCF-7 breast cancer cells and displayed greater cancer cell killing than individual modalities. Therefore, polysaccharide decoration could ensure the co-delivery of GNR and DOX into cancer cells, and the developed GNR-HACH holds great potential for breast cancer treatment.
联合应用具有多种杀伤肿瘤机制的不同治疗方法已成为一种很有前途的抗癌策略。在此，我们报道了一种醛基/邻苯二酚功能化透明质酸（DAHA）和羟乙基壳聚糖（HECS）修饰的金纳米棒（GNR）平台，用于联合化疗-光热治疗乳腺癌。DAHA 是通过将多巴胺偶联到氧化透明质酸上合成的。该纳米平台是通过 Au-邻苯二酚键将 DAHA 修饰到 GNR 上，通过席夫碱键将 DOX 偶联到 DAHA 部分，然后再涂覆 HECS 夹层以实现电荷反转和透明质酸冠用于肿瘤细胞靶向。所得的纳米平台 GNR-HACH 表现出酸触发的表面电荷反转和 pH/NIR 双重响应药物释放行为。该纳米平台可以有效地被 MCF-7 乳腺癌细胞内化，并显示出比单一模式更高的癌细胞杀伤能力。因此，多糖修饰可以确保 GNR 和 DOX 共同递送到癌细胞中，所开发的 GNR-HACH 在乳腺癌治疗方面具有很大的潜力。
