Sun Jingjun, Zhao Haiyan, Xu Weixuan, Jiang Guo-Qin
Department of Surgery, the Second Affiliated Hospital of Soochow University, Suzhou, China.
Department of Breast Surgery, Affiliated Maternity and Child Health Care Hospital of Nantong University, Nantong, China.
Front Chem. 2022 Sep 19;10:1024177. doi: 10.3389/fchem.2022.1024177. eCollection 2022.
Breast cancer (BC) is one of the most common cancers in women worldwide; however, the successful treatment of BC, especially triple-negative breast cancer (TNBC), remains a significant clinical challenge. Recently, photothermal therapy (PTT), which involves the generation of heat under irradiation to achieve photothermal ablation of BC with minimal invasiveness and outstanding spatial-temporal selectivity, has been demonstrated as a novel therapy that can overcome the drawbacks of chemotherapy or surgery. Significantly, when combining PTT with chemotherapy and/or photodynamic therapy, an enhanced synergistic therapeutic effect can be achieved in both primary and metastatic BC tumors. Thus, this review discusses the recent developments in nanotechnology-based photothermal therapy for the treatment of BC and its metastasis to provide potential strategies for future BC treatment.
乳腺癌（BC）是全球女性中最常见的癌症之一；然而，成功治疗BC，尤其是三阴性乳腺癌（TNBC），仍然是一项重大的临床挑战。最近，光热疗法（PTT），即在照射下产生热量以实现对BC的光热消融，具有微创性和出色的时空选择性，已被证明是一种可以克服化疗或手术缺点的新型疗法。值得注意的是，当将PTT与化疗和/或光动力疗法相结合时，在原发性和转移性BC肿瘤中均可实现增强的协同治疗效果。因此，本综述讨论了基于纳米技术的光热疗法在治疗BC及其转移方面的最新进展，为未来BC治疗提供潜在策略。
