School of Materials Science and Engineering, Nanjing Institute of Technology, Nanjing 211167, China; Jiangsu Key Laboratory of Advanced Structural Materials and Application Technology, Nanjing Institute of Technology, Nanjing 211167, China.
School of Materials Science and Engineering, Southeast University, Nanjing 211189, China; Jiangsu Key Laboratory for Advanced Metallic Materials, Southeast University, Nanjing 211189, China.
Mater Sci Eng C Mater Biol Appl. 2019 Oct;103:109765. doi: 10.1016/j.msec.2019.109765. Epub 2019 May 17.
Fully degradable poly lactic acid based composite reinforced with 20 vol% magnesium alloy wires (MAWs) is prepared for weight bearing bone fracture healing. The degradation behaviors of the composite in the consistent and staged dynamic environments are investigated. The results suggest that dynamic loading would overall accelerate the degradation of the composite. As the loading magnitude increases from 0.2 MPa to 1 MPa or frequency from 0.5 Hz to 2.5 Hz, the degradation rate goes up. Under the staged dynamic loading condition, the degradation behaviors of the composite would show staged change determined by the dynamic loading condition at each stage. A numerical model is proposed to systematically depict the mechanical performances of the composite in the consistent and staged dynamic environments. The composite could theoretically provide sufficient stabilization for >8 weeks in a feasible dynamic environment to achieve successful bone fracture healing.
用于承重骨骨折愈合的 20vol%镁合金丝（MAWs）增强全可降解聚乳酸基复合材料。研究了复合材料在一致和分级动态环境中的降解行为。结果表明，动态加载会整体加速复合材料的降解。随着加载幅度从 0.2MPa 增加到 1MPa 或频率从 0.5Hz 增加到 2.5Hz，降解速率增加。在分级动态加载条件下，复合材料的降解行为将表现出由每个阶段的动态加载条件决定的阶段性变化。提出了一个数值模型来系统地描述复合材料在一致和分级动态环境中的力学性能。在可行的动态环境中，该复合材料理论上可以提供超过 8 周的稳定支撑，以实现成功的骨骨折愈合。
