聚乳酸/镁复合薄膜的加速水解降解：材料性能与干细胞相互作用

Accelerated Hydrolytic Degradation of PLA/Magnesium Composite Films: Material Properties and Stem Cell Interaction.

作者信息

Fabi Valentina, Valicenti Maria Luisa, Dominici Franco, Morena Francesco, Torre Luigi, Martino Sabata, Armentano Ilaria

机构信息

Department of Economics, Engineering, Society and Business Organization (DEIM), University of Tuscia, Largo dell'Università snc, 01100 Viterbo, Italy.

Department of Chemistry, Biology and Biotechnologies, University of Perugia, 06123 Perugia, Italy.

出版信息

Polymers (Basel). 2025 Jul 27;17(15):2052. doi: 10.3390/polym17152052.

DOI:10.3390/polym17152052

PMID:40808100

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12349473/

Abstract

The accelerated hydrolytic degradation of poly(L-lactide) (PLA)/magnesium (Mg) composite films was investigated to elucidate the influence of surface modification of Mg particles on the degradation behavior and characteristics of PLA composites. Accelerated degradation studies were conducted at 60 °C in a pH 7.4 phosphate-buffered solution over 7 weeks, with degradation monitored using several techniques: mass loss, water absorption, thermal analysis, and Raman spectroscopy. The results indicated that all composite films experienced more than 90% mass loss at the end of experiment; however, PLA/5MgTT and PLA/5MgPEI exhibited the highest resistance to degradation, likely due to the protective effect of the surface modification induced by thermal treatment and polyethylenimine (PEI). Notably, these characteristics did not compromise the biocompatibility or osteogenic potential of the films, which remained comparable to the control samples when tested on human bone marrow multipotent mesenchymal/stromal cells.

摘要

研究了聚（L-丙交酯）（PLA）/镁（Mg）复合薄膜的加速水解降解，以阐明Mg颗粒表面改性对PLA复合材料降解行为和特性的影响。在60°C的pH 7.4磷酸盐缓冲溶液中进行了7周的加速降解研究，使用多种技术监测降解情况：质量损失、吸水率、热分析和拉曼光谱。结果表明，所有复合薄膜在实验结束时质量损失均超过90%；然而，PLA/5MgTT和PLA/5MgPEI表现出最高的抗降解性，这可能归因于热处理和聚乙烯亚胺（PEI）诱导的表面改性的保护作用。值得注意的是，这些特性并未损害薄膜的生物相容性或成骨潜力，在对人骨髓多能间充质/基质细胞进行测试时，其与对照样品相当。