Key Laboratory of Bionic Engineering, Ministry of Education, Jilin University, Changchun 130022, China; College of Chemistry, Jilin University, Changchun 130022, China.
College of Chemistry, Jilin University, Changchun 130022, China.
Mater Sci Eng C Mater Biol Appl. 2019 Oct;103:109797. doi: 10.1016/j.msec.2019.109797. Epub 2019 May 28.
Many conventional bactericidal materials exhibit antibacterial activities by releasing biocides, which potentially trigger antibiotic resistance and cause environmental concerns. In the present work, we reported the development of antibacterial nanocomposite membrane containing upconversion nanoparticles (UCNPs) by electrospinning. The nanocomposite membrane itself was not bactericidal but exhibits strongly antimicrobial performance on demand as activated by near-infrared (NIR) light. Upon just 5 min of NIR irradiation, the UCNPs in the nanocomposite membrane could trigger the release of reactive oxygen species (ROS) from photosensitizers, which could kill both Gram-positive Staphylococcus aureus (94.5%) and Gram-negative Escherichia coli (93.2%) rapidly. Moreover, the bactericidal activity could be effectively maintained for at least four cycles. In addition, the nanocomposite membrane showed no adverse effects on the mammalian cells, as verified by a cytotoxicity assay. This work provided a new strategy in designing novel antibacterial materials that might be potentially applied in infection-resistant and wound healing.
许多传统的杀菌材料通过释放杀生剂来表现出抗菌活性，这可能会引发抗生素耐药性并引起环境问题。在本工作中，我们通过静电纺丝报道了含有上转换纳米粒子（UCNP）的抗菌纳米复合膜的开发。纳米复合膜本身没有杀菌作用，但在近红外（NIR）光的激活下按需表现出强烈的抗菌性能。仅仅经过 5 分钟的 NIR 照射，纳米复合膜中的 UCNP 就可以触发光增敏剂释放活性氧（ROS），从而迅速杀死革兰氏阳性金黄色葡萄球菌（94.5%）和革兰氏阴性大肠杆菌（93.2%）。此外，杀菌活性至少可以有效维持四个循环。此外，细胞毒性测定证实，纳米复合膜对哺乳动物细胞没有不良影响。这项工作为设计新型抗菌材料提供了一种新策略，这种材料可能潜在地应用于抗感染和伤口愈合。
