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社会经济地位与心力衰竭患者一年死亡率风险:一项全国范围内基于登记的队列研究。

Socioeconomic position and one-year mortality risk among patients with heart failure: A nationwide register-based cohort study.

机构信息

Department of Research, Danish Heart Foundation, Denmark.

Department of Public Health, University of Copenhagen, Denmark.

出版信息

Eur J Prev Cardiol. 2020 Jan;27(1):79-88. doi: 10.1177/2047487319865946. Epub 2019 Jul 26.

DOI:10.1177/2047487319865946
PMID:31349771
Abstract

AIMS

We sought to determine whether socioeconomic position affects the survival of patients with heart failure treated in a national healthcare system.

METHODS

We linked national Danish registers, identified 145,690 patients with new-onset heart failure between 2000 and 2015, and obtained information on education and income levels. We analysed differences in survival by income quartile and educational level using multiple Cox regression, stratified by sex. We standardised one-year mortality risks according to income level by age, year of diagnosis, cohabitation status, educational level, comorbidities and medical treatment of all patients. We standardised one-year mortality risk according to educational level by age and year of diagnosis.

RESULTS

One-year mortality was inversely related to income. In women the standardised average one-year mortality risk was 28.0% in the lowest income quartile and 24.3% in the highest income quartile, a risk difference of -3.8% (95% confidence interval (CI) -4.9% to -2.6%). In men the standardised one-year mortality risk was 26.1% in the lowest income quartile and 20.2% in the highest income quartile, a risk difference of -5.8% (95% CI -6.8% to -4.9%). Similar gradients in standardised mortality were present between the highest and lowest educational levels: -6.6% (95% CI -9.6% to -3.5%) among women and -5.0% (95% CI -6.3% to -3.7%) among men.

CONCLUSIONS

Income and educational level affect the survival of patients with heart failure, even in a national health system. Research is needed to investigate how socioeconomic differences affect survival.

摘要

目的

我们旨在确定在国家卫生保健系统中治疗的心力衰竭患者的社会经济地位是否影响其生存。

方法

我们将全国丹麦登记处进行了关联,确定了 2000 年至 2015 年间新发心力衰竭的 145690 名患者,并获取了教育和收入水平的相关信息。我们使用多 Cox 回归分析了按收入四分位数和教育水平分层的患者生存差异。我们根据所有患者的年龄、诊断年份、同居状况、教育水平、合并症和治疗方法,按收入水平对一年死亡率风险进行了标准化。我们根据年龄和诊断年份,按教育水平对一年死亡率风险进行了标准化。

结果

一年死亡率与收入呈负相关。在女性中,最低收入四分位数的标准化平均一年死亡率风险为 28.0%,最高收入四分位数为 24.3%,风险差异为-3.8%(95%置信区间为-4.9%至-2.6%)。在男性中,最低收入四分位数的标准化一年死亡率风险为 26.1%,最高收入四分位数为 20.2%,风险差异为-5.8%(95%置信区间为-6.8%至-4.9%)。在最高和最低教育水平之间也存在类似的死亡率标准化梯度:女性为-6.6%(95%置信区间为-9.6%至-3.5%),男性为-5.0%(95%置信区间为-6.3%至-3.7%)。

结论

收入和教育水平会影响心力衰竭患者的生存,即使在国家卫生保健系统中也是如此。需要研究社会经济差异如何影响生存。

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