Orthopedic Department, San Gerardo Hospital, University of Milano - Bicocca, Monza, Italy.
Department of Paediatric Orthopaedics, Saint Joseph Hospital, Marseille, France.
Ital J Pediatr. 2019 Jul 26;45(1):91. doi: 10.1186/s13052-019-0685-z.
Brodie's abscess is a form of chronic pyogenic osteomyelitis that usually affects the cancellous part of the long bones in children. Its treatment is represented by antibiotic therapy alone or in association with surgical procedures.
A 12-years-old male affected by a Brodie's abscess of the tibia involving the distal growth plate was admitted to the Pediatric Department for a conservative treatment. After several attempts of antibiotic therapy interrupted for intolerance manifestations he was surgically treated with bioactive glass BAG-S53P4 (BonAlive, BonAlive Biomaterials Ltd., Biolinja, Finland), with excellent results.
In our experience BAG-S53P4 has proven to be an effective bone substitute without side effects even in the pediatric population. In our case it eradicated the infection without interfere with the growth; neither epiphysiodesis nor other disorders were found during the follow-up. For the publication of this case report we followed the CARE guidelines for good clinical case reports; the parents gave consent for publication.
布氏脓肿是一种慢性化脓性骨髓炎，通常影响儿童长骨的松质部分。其治疗方法主要为抗生素治疗单独或联合手术治疗。
一名 12 岁男性，患有胫骨布氏脓肿，累及生长板远端，因不耐受表现，在儿科接受保守治疗。多次尝试抗生素治疗后中断，遂接受生物活性玻璃 BAG-S53P4（BonAlive，BonAlive Biomaterials Ltd.，Biolinja，芬兰）的手术治疗，效果极佳。
根据我们的经验，BAG-S53P4 被证明是一种有效的骨替代物，即使在儿科人群中也没有副作用。在我们的病例中，它消除了感染，而没有干扰生长；在随访过程中没有发现骺板融合或其他疾病。为了发表这个病例报告，我们遵循了良好临床病例报告的 CARE 指南；家长同意发表。
