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Establishing a prognostic threshold for total copy number variation within adult IDH-mutant grade II/III astrocytomas.

作者信息

Mirchia Kanish, Snuderl Matija, Galbraith Kristyn, Hatanpaa Kimmo J, Walker Jamie M, Richardson Timothy E

机构信息

Department of Pathology, State University of New York, Upstate Medical University, Syracuse, NY, 13210, USA.

Department of Pathology, New York University Langone Health, New York City, NY, 10016, USA.

出版信息

Acta Neuropathol Commun. 2019 Jul 26;7(1):121. doi: 10.1186/s40478-019-0778-3.

DOI:10.1186/s40478-019-0778-3
PMID:31349875
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6660955/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c6f/6660955/80cc99c3de0c/40478_2019_778_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c6f/6660955/80cc99c3de0c/40478_2019_778_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c6f/6660955/80cc99c3de0c/40478_2019_778_Fig1_HTML.jpg

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Targeted copy number analysis outperforms histologic grading in predicting patient survival for WHO grades II/III IDH-mutant astrocytomas.在预测世界卫生组织II/III级异柠檬酸脱氢酶(IDH)突变型星形细胞瘤患者的生存率方面,靶向拷贝数分析优于组织学分级。
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本文引用的文献

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Acta Neuropathol Commun. 2019 Jun 10;7(1):92. doi: 10.1186/s40478-019-0746-y.
2
Genome-Wide Analysis of Glioblastoma Patients with Unexpectedly Long Survival.胶质母细胞瘤患者超长生存期的全基因组分析。
J Neuropathol Exp Neurol. 2019 Jun 1;78(6):501-507. doi: 10.1093/jnen/nlz025.
3
Satisfying your neuro-oncologist: a fast approach to routine molecular glioma diagnostics.令神经肿瘤学家满意:一种快速进行常规分子胶质瘤诊断的方法。
T2-FLAIR 错配信号预测 IDH 突变星形细胞瘤中的 DNA 甲基化亚类和 CDKN2A/B 状态。
Clin Cancer Res. 2024 Aug 15;30(16):3512-3519. doi: 10.1158/1078-0432.CCR-24-0311.
4
Prognostic value of DNA methylation subclassification, aneuploidy, and CDKN2A/B homozygous deletion in predicting clinical outcome of IDH mutant astrocytomas.DNA 甲基化亚分类、非整倍体和 CDKN2A/B 纯合缺失在预测 IDH 突变星形细胞瘤临床结局中的预后价值。
Neuro Oncol. 2024 Jun 3;26(6):1042-1051. doi: 10.1093/neuonc/noae009.
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Genetic alterations that deregulate RB and PDGFRA signaling pathways drive tumor progression in IDH2-mutant astrocytoma.遗传改变导致 RB 和 PDGFRA 信号通路失活,从而推动 IDH2 突变星形细胞瘤的肿瘤进展。
Acta Neuropathol Commun. 2023 Nov 27;11(1):186. doi: 10.1186/s40478-023-01683-x.
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Acta Neuropathol Commun. 2022 Aug 17;10(1):115. doi: 10.1186/s40478-022-01420-w.
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is a novel independent predictor of prognosis in LGG patients with mutation.是具有 突变的低级别胶质瘤(LGG)患者预后的一种新型独立预测指标。
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Neuro Oncol. 2018 Nov 12;20(12):1682-1683. doi: 10.1093/neuonc/noy128.
4
Genetic and Epigenetic Features of Rapidly Progressing IDH-Mutant Astrocytomas.快速进展型 IDH 突变星形细胞瘤的遗传和表观遗传特征。
J Neuropathol Exp Neurol. 2018 Jul 1;77(7):542-548. doi: 10.1093/jnen/nly026.
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Same-day genomic and epigenomic diagnosis of brain tumors using real-time nanopore sequencing.使用实时纳米孔测序对脑肿瘤进行同日基因组和表观基因组诊断。
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