辅酶 Q10 和维生素 E 对多囊卵巢综合征女性代谢及内脏肥胖的独立和累加作用

Independent and Additive Effects of Coenzyme Q10 and Vitamin E on Cardiometabolic Outcomes and Visceral Adiposity in Women With Polycystic Ovary Syndrome.

机构信息

Department of Biochemistry and Diet Therapy, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran; Student Research Committee, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.

Department of Biochemistry and Diet Therapy, Nutrition Research Center, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.

出版信息

Arch Med Res. 2019 Feb;50(2):1-10. doi: 10.1016/j.arcmed.2019.04.004. Epub 2019 May 21.

DOI:10.1016/j.arcmed.2019.04.004

PMID:31349945

Abstract

BACKGROUND

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in reproductive age women.

OBJECTIVE

This study was conducted to investigate the effects of CoQ10 and/or vitamin E on cardiometabolic outcomes in patients with PCOS.

METHODS

This randomized clinical trial was carried out among 86 women with PCOS. Patients were assigned to take CoQ10, vitamin E, CoQ10 plus vitamin E or placebo for 8 weeks. Fasting blood samples were obtained at the beginning and end of the study.

RESULTS

A significant decrease in serum triglycerides (TG) (p <0.001) was found following the administration of CoQ10 and/or vitamin E supplements compared with the placebo group. Supplementation with CoQ10 and vitamin E failed to affect total cholesterol levels. However, co-administration of CoQ10 and vitamin E resulted in a significant decrease in serum total cholesterol levels (9.92 [15.11, 4.74]). Additionally, only the combination of supplements was able to significantly reduce low-density lipoprotein-cholesterol (LDL-C) (‒9.63 [‒15.34, ‒3.92]), increase high-density lipoprotein-cholesterol (HDL-C) (2.33 [0.51, 4.16), reduce atherogenic coefficient (AC) (‒0.29 [‒0.43, ‒0.16], p = 0.03) and decrease visceral adiposity index (VAI) values. Co-Q10 and vitamin E (alone or in combination) had significant effects on non-HDL-C (p = 0.004), atherogenic Index of Plasma (AIP) (p = <0.001) and lipid accumulation product (LAP) (p <0.001) and SBP (p = 0.005). However, the reduction in DBP was statistically significant only for patients who received combined supplementations (p = 0.04).

CONCLUSIONS

In conclusion, CoQ10, vitamin E (alone or in combination) had beneficial effects on cardiometabolic outcomes among women with PCOS.

摘要

背景

多囊卵巢综合征（PCOS）是育龄妇女中最常见的内分泌疾病。

目的

本研究旨在探讨辅酶 Q10 和/或维生素 E 对 PCOS 患者心脏代谢结局的影响。

方法

本随机临床试验纳入了 86 例 PCOS 患者。患者被分配服用辅酶 Q10、维生素 E、辅酶 Q10 加维生素 E 或安慰剂 8 周。在研究开始和结束时采集空腹血样。

结果

与安慰剂组相比，辅酶 Q10 和/或维生素 E 补充剂治疗后血清甘油三酯（TG）显著下降（p<0.001）。辅酶 Q10 和维生素 E 补充剂未能影响总胆固醇水平。然而，辅酶 Q10 和维生素 E 联合使用可显著降低血清总胆固醇水平（9.92 [15.11，4.74]）。此外，只有补充剂联合使用才能显著降低低密度脂蛋白胆固醇（LDL-C）（-9.63 [-15.34，-3.92]），增加高密度脂蛋白胆固醇（HDL-C）（2.33 [0.51，4.16]），降低致动脉粥样硬化系数（AC）（-0.29 [-0.43，-0.16]，p=0.03）和降低内脏脂肪指数（VAI）值。辅酶 Q10 和维生素 E（单独或联合使用）对非高密度脂蛋白胆固醇（p=0.004）、血浆致动脉粥样硬化指数（AIP）（p<0.001）和脂质堆积产物（LAP）（p<0.001）和收缩压（SBP）（p=0.005）有显著影响。然而，只有接受联合补充的患者舒张压下降有统计学意义（p=0.04）。