Ankara Etlik Zubeyde Hanim Women's Health Teaching and Researching Hospital, Women's Health Department, Ankara, Turkey.
Ankara Etlik Zubeyde Hanim Women's Health Teaching and Researching Hospital, Women's Health Department, Ankara, Turkey.
Arch Med Res. 2019 Feb;50(2):36-43. doi: 10.1016/j.arcmed.2019.05.010. Epub 2019 Jun 3.
Non-ionizing radiation is related with many pathologies.
Determine association between non-ionizing radiation and endometrial hyperplasia.
Fifty oopherectomized Wistar albino rats were administered Estradiol hemihydrate (4 mg/kg) to induce hyperplasia, and were exposed to 1800 MHz radiation created by a mobile phone and a signal generator working as base station. This study was carried out with 5 groups in two phases. The study groups were. Control group without any exposure; group receiving estrogen in first phase of the study; group receiving estrogen in both phases; group receiving estrogen in the first phase and exposed to non-ionizing radiation during second phase and group taking estrogen in both phases and exposed to non-ionizing radiation during the second phase. Following both phases, uterine horns were excised and evaluated based on glandular density (GD), epithelial cell height (ECH), and luminal epithelial cell height (LECH).
Estrogen increased all parameters during both phases (LECH, GD, and ECH values were 12,2 vs. 16,5 (p = 0.001), 34 vs. 47 (p <0.001), and 201 vs. 376.6 (p = 0.001), respectively during the first phase; LECH, GD and ECH values were 13,2 vs. 20,3 (p <0.001), 35.5 vs. 65,5 (p <0.001), 219.9 vs. 419.6 (p <0.001), respectively, during the second phase).Non-ionizing radiation increased all values without estrogen exposure (LECH, GD and ECH values were 13,2 vs. 17,2 (p = 0,074), 35,5 vs. 59 (p = 0.074), and 219 vs. 318.3 (p <0.001), respectively) or with estrogen exposure (LECH, GD, and ECH, values were 20,3 vs. 22,8 (p = 0,168), 65,5 vs. 77 (p = 0,058), and 419,6 vs. 541,6 (p = 0.004), respectively).
Non-ionizing radiation progressed endometrial hyperplasia in an experimental rat model with/without estrogen exposure.
非电离辐射与许多病理学有关。
确定非电离辐射与子宫内膜增生之间的关系。
将 50 只去卵巢 Wistar 白化大鼠给予雌二醇半水合物（4mg/kg）以诱导增生，并暴露于移动电话和信号发生器产生的 1800MHz 辐射下，作为基站。这项研究分两个阶段进行了 5 组。研究组为：无任何暴露的对照组；第一阶段接受雌激素的组；两阶段均接受雌激素的组；第一阶段接受雌激素和第二阶段接受非电离辐射的组；两阶段均接受雌激素和第二阶段接受非电离辐射的组。两个阶段结束后，切除子宫角并根据腺体密度（GD）、上皮细胞高度（ECH）和腔上皮细胞高度（LECH）进行评估。
雌激素在两个阶段均增加了所有参数（LECH、GD 和 ECH 值分别在第一阶段为 12.2 对 16.5（p=0.001）、34 对 47（p<0.001）和 201 对 376.6（p=0.001）；在第二阶段分别为 13.2 对 20.3（p<0.001）、35.5 对 65.5（p<0.001）和 219.9 对 419.6（p<0.001））。非电离辐射增加了所有无雌激素暴露的数值（LECH、GD 和 ECH 值分别在第一阶段为 13.2 对 17.2（p=0.074）、35.5 对 59（p=0.074）和 219 对 318.3（p<0.001）；在第二阶段分别为 13.2 对 17.2（p=0.074）、35.5 对 59（p=0.074）和 219 对 318.3（p<0.001））或有雌激素暴露（LECH、GD 和 ECH 值分别在第一阶段为 20.3 对 22.8（p=0.168）、65.5 对 77（p=0.058）和 419.6 对 541.6（p=0.004）；在第二阶段分别为 20.3 对 22.8（p=0.168）、65.5 对 77（p=0.058）和 419.6 对 541.6（p=0.004））。
非电离辐射在有/无雌激素暴露的实验性大鼠模型中促进了子宫内膜增生。
