Histopathology Department, National Organization for Drug Control and Research (NODCAR), Egypt.
Zoology Department, Faculty of Science, Cairo University, Egypt.
Reprod Biol. 2019 Sep;19(3):237-244. doi: 10.1016/j.repbio.2019.07.003. Epub 2019 Jul 24.
Liraglutide is a Glucagon-like peptide-1 (GLP-1) analogue used for the treatment of type II diabetes mellitus and obesity. The present study aimed at investigating the effect of Liraglutide in ovarian and uterine tissues in albino rats. 30 female rats were divided into 3 groups, 10 rats each. Group (I) served as control group, group (II) animals administrated therapeutic doses of liraglutide for 5 weeks and group (III) animals were injected with Liraglutide as the pervious group. Then they were left for 2 weeks after drug termination as a recovery period. The biochemical results showed a decrease in the female reproductive hormones profile, luteinizing hormone (LH), follicle stimulating hormone (FSH), estrogen (ER), progesterone (PR) and an increase in the level of testosterone (T). Liraglutide administration caused a significant decrease in the antioxidant markers, glutathione (GSH), catalase (CAT), and superoxide dismutase (SOD) and a significant increase in the activity of malondialdehyde (MDA). The histopathological examination revealed apoptosis of granulosa cells of different types of follicles with an increase in atretic and disorganized follicles. Vacuolar degenerative changes, and Atrophied muscle with sever inflammatory cell infiltrate in endometrium with congested, dilated blood vessels could be detected in uterine tissues. However, most of the deleterious effects of liraglutide decreased after drug discontinuation. In this study, we clarify the harmful effect of the liraglutide on ovarian and uterine tissues, thus potentially causing reproductive health malfunction and reducing the chances of pregnancy.
利拉鲁肽是一种胰高血糖素样肽-1（GLP-1）类似物，用于治疗 2 型糖尿病和肥胖症。本研究旨在研究利拉鲁肽对白化大鼠卵巢和子宫组织的影响。将 30 只雌性大鼠分为 3 组，每组 10 只。第（I）组为对照组，第（II）组动物给予治疗剂量的利拉鲁肽 5 周，第（III）组动物给予利拉鲁肽作为前一组。停药后 2 周为恢复期。生化结果显示，女性生殖激素谱、促黄体生成素（LH）、卵泡刺激素（FSH）、雌激素（ER）、孕激素（PR）水平下降，睾酮（T）水平升高。利拉鲁肽给药导致抗氧化标志物谷胱甘肽（GSH）、过氧化氢酶（CAT）和超氧化物歧化酶（SOD）显著下降，丙二醛（MDA）活性显著升高。组织病理学检查显示，不同类型卵泡的颗粒细胞凋亡，闭锁卵泡增多。子宫内膜出现空泡变性、萎缩性肌退行性变和严重的炎性细胞浸润，血管充血、扩张。然而，停药后，利拉鲁肽的大部分有害作用会降低。在这项研究中，我们阐明了利拉鲁肽对卵巢和子宫组织的有害影响，从而可能导致生殖健康功能障碍，降低怀孕的机会。
