钱草（）和海飘消（）这一对中药对不完全流产大鼠异常子宫出血的疗效。
Efficacy of Qiancao () and Haipiaoxiao (), a traditional Chinese herb pair, on abnormal uterine bleeding in rats with incomplete abortion.
机构信息
Department of Pharmacy, Shanghai Songjiang Fangta Hospital of TCM, Shanghai 201600, China.
Department of Pharmacy, Shanghai TCM-Integrated Hospital, Shanghai 200080, China.
出版信息
J Tradit Chin Med. 2022 Oct;42(5):758-763. doi: 10.19852/j.cnki.jtcm.20220707.002.
Abstract
OBJECTIVE
To investigate the most effective weight ratio of Qiancao () and Haipiaoxiao () used to produce decoction for the treatment of abnormal uterine bleeding (AUB) in rats with incomplete abortion, and to study the possible mechanism.
METHODS
The models of AUB were established by incomplete drug abortion with mifepristone and misoprostol in pregnant rats. The therapeutic effects of decoctions made by eight different weight ratios of Qiancao () and Haipiaoxiao () were observed.
RESULTS
Statistical analysis revealed that the most effective weight ratio of Qiancao () and Haipiaoxiao () to treat AUB in this study was 2∶1.
CONCLUSION
The insights gained from this study would improve understanding of the mechanisms involved in the effect of Qiancao () and Haipiaoxiao () on AUB.
摘要
目的
探讨茜草-海螵蛸不同配比对米非司酮和米索前列醇致不完全流产大鼠异常子宫出血的影响，为临床提供最佳用药比例。
方法
采用米非司酮联合米索前列醇构建大鼠不完全流产模型，观察不同比例茜草-海螵蛸水煎液对大鼠异常子宫出血的影响。
结果
统计分析显示，茜草-海螵蛸治疗大鼠异常子宫出血的最佳配比为 2∶1。
结论
本研究为进一步阐明茜草-海螵蛸治疗异常子宫出血的作用机制提供了实验依据。
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