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钱草（）和海飘消（）这一对中药对不完全流产大鼠异常子宫出血的疗效。

Efficacy of Qiancao () and Haipiaoxiao (), a traditional Chinese herb pair, on abnormal uterine bleeding in rats with incomplete abortion.

机构信息

Department of Pharmacy, Shanghai Songjiang Fangta Hospital of TCM, Shanghai 201600, China.

Department of Pharmacy, Shanghai TCM-Integrated Hospital, Shanghai 200080, China.

出版信息

J Tradit Chin Med. 2022 Oct;42(5):758-763. doi: 10.19852/j.cnki.jtcm.20220707.002.

DOI:10.19852/j.cnki.jtcm.20220707.002
PMID:36083483
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9924793/
Abstract

OBJECTIVE

To investigate the most effective weight ratio of Qiancao () and Haipiaoxiao () used to produce decoction for the treatment of abnormal uterine bleeding (AUB) in rats with incomplete abortion, and to study the possible mechanism.

METHODS

The models of AUB were established by incomplete drug abortion with mifepristone and misoprostol in pregnant rats. The therapeutic effects of decoctions made by eight different weight ratios of Qiancao () and Haipiaoxiao () were observed.

RESULTS

Statistical analysis revealed that the most effective weight ratio of Qiancao () and Haipiaoxiao () to treat AUB in this study was 2∶1.

CONCLUSION

The insights gained from this study would improve understanding of the mechanisms involved in the effect of Qiancao () and Haipiaoxiao () on AUB.

摘要

目的

探讨茜草-海螵蛸不同配比对米非司酮和米索前列醇致不完全流产大鼠异常子宫出血的影响，为临床提供最佳用药比例。

方法

采用米非司酮联合米索前列醇构建大鼠不完全流产模型，观察不同比例茜草-海螵蛸水煎液对大鼠异常子宫出血的影响。

结果

统计分析显示，茜草-海螵蛸治疗大鼠异常子宫出血的最佳配比为 2∶1。

结论

本研究为进一步阐明茜草-海螵蛸治疗异常子宫出血的作用机制提供了实验依据。

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本文引用的文献

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Abnormal Uterine Bleeding in the Adolescent.青春期异常子宫出血。
Obstet Gynecol. 2020 Mar;135(3):615-621. doi: 10.1097/AOG.0000000000003693.
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Liraglutide treatment effects on rat ovarian and uterine tissues.利拉鲁肽对大鼠卵巢和子宫组织的治疗作用。
Reprod Biol. 2019 Sep;19(3):237-244. doi: 10.1016/j.repbio.2019.07.003. Epub 2019 Jul 24.
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Biological, Behavioral and Physiological Consequences of Drug-Induced Pregnancy Termination at First-Trimester Human Equivalent in an Animal Model.在动物模型中，药物诱导的相当于人类孕早期终止妊娠的生物学、行为学和生理学后果。
Front Neurosci. 2019 May 29;13:544. doi: 10.3389/fnins.2019.00544. eCollection 2019.
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Resolving DOAC interference on aPTT, PT, and lupus anticoagulant testing by the use of activated carbon.使用活性炭解决 DOAC 对 aPTT、PT 和狼疮抗凝物检测的干扰。
J Thromb Haemost. 2019 Aug;17(8):1354-1362. doi: 10.1111/jth.14488. Epub 2019 Jun 12.
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Chinese herbal medicines for the treatment of non-structural abnormal uterine bleeding in perimenopause: A systematic review and a meta-analysis.中药治疗围绝经期非结构性异常子宫出血的系统评价和荟萃分析。
Complement Ther Med. 2018 Dec;41:252-260. doi: 10.1016/j.ctim.2018.09.021. Epub 2018 Sep 26.
7
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8
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Neuro Endocrinol Lett. 2018 Feb;38(8):537-543.
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