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日本全国旁观者-患者关系及院外心搏骤停后 1 个月结局登记研究:一项前瞻性、全国性、基于人群的观察研究

Citizen bystander-patient relationship and 1-month outcomes after out-of-hospital cardiac arrest of cardiac origin from the All-Japan Utstein Registry: a prospective, nationwide, population-based, observational study.

机构信息

Cardiology, Fukuoka University, Fukuoka, Japan.

Biochemistry, Fukuoka University, Fukuoka, Japan.

出版信息

BMJ Open. 2019 Jul 26;9(7):e024715. doi: 10.1136/bmjopen-2018-024715.

Abstract

OBJECTIVES

The presence of a bystander witness is a crucial predictor of patient survival after out-of-hospital cardiac arrest (OHCA). However, the differences in survival and neurological outcomes among different types of citizen bystanders are not well understood.

DESIGN

We analysed data from the All-Japan Utstein Registry, a prospective, nationwide, population-based, observational study that was started in January 2005.

SETTING

The registry includes all patients with OHCA who were transported to the hospital by emergency medical service (EMS) in Japan. The type of citizen bystander was classified as family member, friend, colleague, passerby or other.

PARTICIPANTS

We analysed 210 642 patients in the registry who were 18 years or older and experienced OHCA of cardiac origin witnessed by a citizen bystander between 2005 and 2014.

PRIMARY AND SECONDARY OUTCOME MEASURES

The main outcomes were 1 month survival and 1 month survival with minimal neurological impairment.

RESULTS

Of the citizen bystander-witnessed cases, 65.1% (137 147/210 642) were witnessed by a family member. However, among patients who survived to 1 month and who had a favourable 1 month neurological outcome, much lower proportions (53.9% (10 907/20 239) and 48.9% (5722/11 696)) were witnessed by a family member. Witness by a friend, colleague or passerby was associated with good 1 month neurological function, after controlling for the patient's age, first recorded rhythm, gender, bystander cardiopulmonary resuscitation (CPR), use of a public-access automated external defibrillator, dispatcher instructions, collapse-call time and response time compared with witness by a family member (friend: OR 1.35, 95% CI 1.24 to 1.46, colleague: OR 1.63, 95% CI 1.33 to 1.98, passerby: OR 1.60, 95% CI 1.39 to 1.84).

CONCLUSIONS

One-month survival and favourable1 month neurological outcome of patients with OHCA of cardiac origin witnessed by a family member were worse than those in cases witnessed by a friend, colleague or passerby, independent of the patient characteristics and the response of EMS.

摘要

目的

旁观者的存在是院外心脏骤停(OHCA)后患者存活的重要预测因素。然而,不同类型的公民旁观者在生存和神经结局方面的差异尚不清楚。

设计

我们分析了 2005 年 1 月开始的全日本 Utstein 注册中心的前瞻性、全国性、基于人群的观察性研究的数据。

地点

该注册中心包括日本由紧急医疗服务(EMS)转运至医院的所有 OHCA 患者。公民旁观者的类型分为家庭成员、朋友、同事、路人或其他。

参与者

我们分析了 2005 年至 2014 年期间由公民旁观者目击的 18 岁及以上、由心脏引起的 OHCA 且有旁观者目击的注册中心 210642 例患者。

主要和次要结局测量

主要结局为 1 个月生存率和 1 个月生存率伴最小神经功能障碍。

结果

在有公民旁观者目击的病例中,65.1%(137147/210642)由家庭成员目击。然而,在存活至 1 个月且神经结局良好的患者中,家庭成员目击的比例要低得多(53.9%(10907/20239)和 48.9%(5722/11696))。目击由朋友、同事或路人见证,与 1 个月时良好的神经功能有关,在控制患者年龄、首次记录节律、性别、旁观者心肺复苏(CPR)、使用公共自动体外除颤器、调度员指令、停搏-呼叫时间和反应时间后与家庭成员目击相比(朋友:比值比 1.35,95%可信区间 1.24 至 1.46;同事:比值比 1.63,95%可信区间 1.33 至 1.98;路人:比值比 1.60,95%可信区间 1.39 至 1.84)。

结论

与由朋友、同事或路人目击相比,家庭成员目击的 OHCA 心脏起源患者的 1 个月生存率和良好的 1 个月神经结局更差,独立于患者特征和 EMS 的反应。

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