Department of Internal Medicine, Section on Gerontology & Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Curr Hypertens Rep. 2019 Jul 26;21(9):70. doi: 10.1007/s11906-019-0973-4.
This is a review of available data on the effects of blood pressure and statins on cognition.
Recent randomized clinical trials have shown that intensive control of systolic blood pressure in older adults prevented the development of mild cognitive impairment (MCI) and the combined effects of MCI and probable dementia. Previous randomized clinical trials have suggested that statin use may prevent a decline in cognition; however, no randomized clinical trials have clearly shown evidence of statin's either positive or negative effect on cognition. Continued follow-up of SPRINT-MIND participants is crucial to evaluate the long-term effects of intensive systolic blood pressure control on the prevention of cognitive decline. A well-conducted and adequately powered randomized control trial is needed to evaluate the effect of statins on cognition, especially for primary prevention of the cognitive decline in aging.
本文回顾了血压和他汀类药物对认知功能影响的现有数据。
最近的随机临床试验表明，老年患者强化收缩压控制可预防轻度认知障碍（MCI）和 MCI 与可能痴呆的联合发生。先前的随机临床试验表明，他汀类药物的使用可能会阻止认知能力下降；然而，没有随机临床试验明确表明他汀类药物对认知功能有积极或消极的影响。SPRINT-MIND 参与者的持续随访对于评估强化收缩压控制对预防认知能力下降的长期效果至关重要。需要进行一项设计良好且充分有力的随机对照试验，以评估他汀类药物对认知功能的影响，特别是评估他汀类药物在衰老导致认知能力下降的一级预防中的作用。
