Rubin C T, Pratt G W, Porter A L, Lanyon L E, Poss R
Department of Orthopaedics, State University of New York, Stony Brook 11794-8181.
Calcif Tissue Int. 1988 May;42(5):309-12. doi: 10.1007/BF02556365.
An animal model was used to examine the use of noninvasive transmission ultrasound to measure changes in bone mass which occur following disuse. Unilateral achilles tenectomy was performed on the left leg of eight adult sheep. Following a 12-week period of nonweight bearing, presacrifice transmission ultrasound measurements were taken across the calcanei of the intact and the experimental limbs and compared with those values taken postoperatively. Following specimen harvest, cross-sectional areas of the bones were quantified by microradiography and stereology, and compared with the in vivo ultrasound measurements. There was an average of 8.6% less total bone area, and 18.0% less trabecular volume fraction in the experimental nonweight-bearing limbs as compared with control intact calcanei. The difference in bone mass was associated with a 9.0% decrease in the velocity of sound from the postoperative to the presacrifice ultrasound measurements taken from the experimental calcanei, and a 2.3% increase in the control calcanei. The velocity of sound was found by the Student's t test to be a highly reliable discriminator between the experimental and control limbs.
使用动物模型来研究无创性透射超声在测量废用后发生的骨量变化中的应用。对8只成年绵羊的左腿进行单侧跟腱切断术。在12周的非负重期后，在处死前对完整肢体和实验肢体的跟骨进行透射超声测量，并与术后测量值进行比较。标本采集后，通过微放射摄影术和体视学对骨骼的横截面积进行量化，并与体内超声测量值进行比较。与对照完整跟骨相比，实验性非负重肢体的总骨面积平均减少8.6%，小梁体积分数平均减少18.0%。骨量差异与实验性跟骨从术后到处死前超声测量的声速下降9.0%以及对照跟骨声速增加2.3%有关。通过学生t检验发现，声速是实验肢体和对照肢体之间高度可靠的判别指标。
