天然药物大黄素包封沸石咪唑酯骨架及其作为抗菌剂的应用。
Natural drug physcion encapsulated zeolitic imidazolate framework, and their application as antimicrobial agent.
机构信息
State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing, PR China.
State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing, PR China.
出版信息
Colloids Surf B Biointerfaces. 2019 Oct 1;182:110364. doi: 10.1016/j.colsurfb.2019.110364. Epub 2019 Jul 15.
In this study, we have encapsulated natural physcion (PHY) drug loading into metal-organic frameworks MOFs, zeolitic imidazolate frameworks (ZIFs) through straight-forward nano-precipitation technique. The synthesized PHY@ZIF-8 indicated high drug loading encapsulation efficiency i.e. 88%, whereas, drug loading capacity was found to be 11.49%. The characterization of PHY loaded-ZIF 8 (PHY@ZIF-8) was carried out by powder x-ray diffraction (PXRD), transmission electron microscopy (TEM), scanning electron microscopy (SEM), thermal gravimetric analysis (TGA), and FT-IR methods. The release of PHY loaded in ZIF-8 was 88.72% at pH 5.0 which is approximately three time higher than its release in physiological system with pH 7.4 (27.61%). The remarkable stability of PHY@ZIF-8 NPs even after 25 days stem it as an effective and stable candidate. Furthermore, the antibacterial activity of pure PHY, ZIF-8 and PHY@ZIF-8 were investigated against gram negative strains and gram positive strain. The PHY@ZIF-8 showed maximum growth inhibition zones against all microorganism as compare to pure PHY. We hope that this model drug could have the potential ability for treatment of various infectious diseases.
在这项研究中，我们通过简单的纳米沉淀技术将天然大黄素（PHY）药物负载到金属有机骨架 MOFs、沸石咪唑酯骨架（ZIFs）中。合成的 PHY@ZIF-8 表现出高的药物负载包封效率（即 88%），而药物负载能力为 11.49%。用粉末 X 射线衍射（PXRD）、透射电子显微镜（TEM）、扫描电子显微镜（SEM）、热重分析（TGA）和傅里叶变换红外光谱（FT-IR）方法对负载 PHY 的 ZIF-8（PHY@ZIF-8）进行了表征。在 pH 5.0 时，负载在 ZIF-8 中的 PHY 的释放率为 88.72%，大约是其在生理系统 pH 7.4 时释放率（27.61%）的三倍。即使在 25 天后，PHY@ZIF-8 NPs 的稳定性也非常显著，这使其成为一种有效的稳定候选物。此外，我们还研究了纯 PHY、ZIF-8 和 PHY@ZIF-8 对革兰氏阴性菌和革兰氏阳性菌的抗菌活性。与纯 PHY 相比，PHY@ZIF-8 对所有微生物的最大生长抑制区显示出最大的抑制活性。我们希望这种模型药物具有治疗各种传染病的潜力。
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