Pharmaceutical College, Henan University, Kaifeng, People's Republic of China.
College of Food Science and Technology, Nanjing Agricultural University, Nanjing, People's Republic of China.
J Food Biochem. 2019 Apr;43(4):e12796. doi: 10.1111/jfbc.12796. Epub 2019 Feb 21.
Rosa rugosa aqueous polyphenol (RAP) is a kind of polyphenol from Rosa rugosa flower tea. In this study, the antiaging activities of RAP were studied in the model organism Caenorhabditis elegans. UHPLC-HESI-MS/MS was employed to identify the specific phenolic profile, revealing that there were 23 types of phenolic compounds in RAP and that quercetin glycoside was the principal component. RAP increased the mean lifespan of C. elegans and enhanced the thermotolerance and resistance to oxidative stress of C. elegans in a concentration-dependent manner. Furthermore, RAP showed powerful antioxidant effects in vitro and strong protection against oxidative DNA damage. RAP significantly improved the levels of total superoxide dismutase and total antioxidant capacity of C. elegans. In conclusion, RAP has antiaging effects on C. elegans, which might be related to its powerful antioxidant effects both in vitro and in vivo. PRACTICAL APPLICATIONS: In recent years, chronic diseases associated with aging have had a profound impact on quality of life. Many healthy foods have antiaging properties, especially flower teas, such as those made from Rosa rugosa. Our results indicated that Rosa rugosa tea is good for health and that RAP could potentially be developed as a bioactive product that could be used to combat aging.
玫瑰茄水多酚（RAP）是一种从玫瑰茄花茶中提取的多酚。本研究以模式生物秀丽隐杆线虫为对象，研究了 RAP 的抗衰老活性。采用 UHPLC-HESI-MS/MS 鉴定了 RAP 的特定酚类谱，结果表明 RAP 中含有 23 种酚类化合物，槲皮素糖苷是主要成分。RAP 能剂量依赖性地延长秀丽隐杆线虫的平均寿命，增强秀丽隐杆线虫的耐热性和抗氧化应激能力。此外，RAP 在体外具有强大的抗氧化作用，能强烈保护秀丽隐杆线虫免受氧化 DNA 损伤。RAP 能显著提高秀丽隐杆线虫的总超氧化物歧化酶和总抗氧化能力水平。综上所述，RAP 对秀丽隐杆线虫具有抗衰老作用，这可能与其在体外和体内强大的抗氧化作用有关。实际应用：近年来，与衰老相关的慢性疾病对生活质量产生了深远的影响。许多具有保健作用的食物都具有抗衰老特性，尤其是花茶，如玫瑰茄茶。我们的研究结果表明，玫瑰茄茶对健康有益，而 RAP 可能具有开发为生物活性产品的潜力，用于对抗衰老。
