来自[具体来源未提及]的多酚通过胰岛素信号通路延长了[具体生物未提及]的寿命并增强了其对压力的抵抗力。
Polyphenols from Extended the Lifespan and Enhanced Resistance to Stress in via the Insulin Signaling Pathway.
作者信息
Chen Tao, Luo Siyuan, Wang Xiaoju, Zhou Yiling, Dai Yali, Zhou Lijun, Feng Shiling, Yuan Ming, Ding Chunbang
机构信息
College of Life Science, Sichuan Agricultural University, Ya'an 625014, China.
出版信息
Antioxidants (Basel). 2021 Oct 30;10(11):1744. doi: 10.3390/antiox10111744.
is widely used as a folk medicine in Asia, but relevant literature on it is rarely reported. We confirmed that polyphenol extract (containing chlorogenic acid, rutin, and luteolin-4-O-glucoside) from (EBL) showed strong antioxidant ability in vitro. Hence, in this work, we applied to further investigate the antioxidant and anti-ageing abilities of EBL in vivo. The results showed that EBL enhanced the survival of under thermal stress by 12.62% and sharply reduced the reactive oxygen species level as well as the content of malonaldehyde. Moreover, EBL increased the activities of antioxidant enzymes such as catalase and superoxide dismutase. Additionally, EBL promoted DAF-16, a transcription factor, into the nucleus. Besides, EBL extended the lifespan of by 17.39%, showing an anti-ageing effect. Different mutants indicated that the insulin/IGF-1 signaling pathway participated in the antioxidant and anti-ageing effect of EBL on .
在亚洲，它被广泛用作民间药物，但相关文献报道很少。我们证实，[某种植物名称]的多酚提取物（含有绿原酸、芦丁和木犀草素-4-O-葡萄糖苷）在体外表现出很强的抗氧化能力。因此，在这项工作中，我们应用[某种植物名称]进一步研究其在体内的抗氧化和抗衰老能力。结果表明，[某种植物名称]在热应激下使[某种生物名称]的存活率提高了12.62%，并显著降低了活性氧水平以及丙二醛含量。此外，[某种植物名称]提高了过氧化氢酶和超氧化物歧化酶等抗氧化酶的活性。另外，[某种植物名称]促进了转录因子DAF-16进入细胞核。此外，[某种植物名称]使[某种生物名称]的寿命延长了17.39%，显示出抗衰老作用。不同的突变体表明，胰岛素/IGF-1信号通路参与了[某种植物名称]对[某种生物名称]的抗氧化和抗衰老作用。
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