Callier Center-Dallas, University of Texas at Dallas, Dallas, Texas.
Center for Brain Health, University of Texas at Dallas, Dallas, Texas.
J Neurotrauma. 2020 Jan 1;37(1):170-177. doi: 10.1089/neu.2018.6331. Epub 2019 Sep 3.
Chronic verbal retrieval deficits have been noted in traumatic brain injury (TBI), but no U.S. Food and Drug Administration-approved interventions are available. The present study investigated whether 10 sessions of 20 min of 1 mA anodal high-definition transcranial direct current stimulation (HD-tDCS) targeting pre-supplementary motor area/dorsal anterior cingulate cortex (preSMA/dACC) compared with sham HD-tDCS would improve verbal retrieval deficits in TBI patients. Improvements in verbal retrieval processes were observed up to 8 weeks post-treatment. Thus, potential dysfunction to verbal retrieval circuitry in TBI appears amenable to remediation through electromodulation with HD tDCS to the preSMA/dACC. Although further studies clarifying mechanisms by which tDCS brought about these improvements will likely inform refinements in the application of this therapeutic technique, the findings suggest the efficacy of using HD-tDCS to target other systems vulnerable to TBI to improve functioning.
慢性言语检索缺陷在创伤性脑损伤（TBI）中已有报道，但目前尚无获得美国食品和药物管理局批准的干预措施。本研究旨在探讨与假刺激相比，10 次 20 分钟 1mA 阳极高清晰度经颅直流电刺激（HD-tDCS）靶向辅助运动区/背侧前扣带皮层（preSMA/dACC）是否会改善 TBI 患者的言语检索缺陷。在治疗后 8 周内观察到言语检索过程的改善。因此，TBI 言语检索回路的潜在功能障碍似乎可以通过对 preSMA/dACC 进行 HD-tDCS 电调节来纠正。尽管进一步的研究阐明了 tDCS 带来这些改善的机制，可能会为这种治疗技术的应用提供改进，但研究结果表明，使用 HD-tDCS 靶向其他易受 TBI 影响的系统来改善功能是有效的。
