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创伤性脑损伤与康复中的神经调节技术:一项范围综述

Traumatic Brain Injury and Neuromodulation Techniques in Rehabilitation: A Scoping Review.

作者信息

Calderone Andrea, Cardile Davide, Gangemi Antonio, De Luca Rosaria, Quartarone Angelo, Corallo Francesco, Calabrò Rocco Salvatore

机构信息

IRCCS Centro Neurolesi Bonino-Pulejo, S.S. 113 Via Palermo, C. da Casazza; 98124 Messina, Italy.

出版信息

Biomedicines. 2024 Feb 16;12(2):438. doi: 10.3390/biomedicines12020438.

Abstract

BACKGROUND AND OBJECTIVES

Traumatic Brain Injury (TBI) is a condition in which an external force, usually a violent blow to the head, causes functional impairment in the brain. Neuromodulation techniques are thought to restore altered function in the brain, resulting in improved function and reduced symptoms. Brain stimulation can alter the firing of neurons, boost synaptic strength, alter neurotransmitters and excitotoxicity, and modify the connections in their neural networks. All these are potential effects on brain activity. Accordingly, this is a promising therapy for TBI. These techniques are flexible because they can target different brain areas and vary in frequency and amplitude. This review aims to investigate the recent literature about neuromodulation techniques used in the rehabilitation of TBI patients.

MATERIALS AND METHODS

The identification of studies was made possible by conducting online searches on PubMed, Web of Science, Cochrane, Embase, and Scopus databases. Studies published between 2013 and 2023 were selected. This review has been registered on OSF (JEP3S).

RESULTS

We have found that neuromodulation techniques can improve the rehabilitation process for TBI patients in several ways. Transcranial Magnetic Stimulation (TMS) can improve cognitive functions such as recall ability, neural substrates, and overall improved performance on neuropsychological tests. Repetitive TMS has the potential to increase neural connections in many TBI patients but not in all patients, such as those with chronic diffuse axonal damage.

CONCLUSIONS

This review has demonstrated that neuromodulation techniques are promising instruments in the rehabilitation field, including those affected by TBI. The efficacy of neuromodulation can have a significant impact on their lives and improve functional outcomes for TBI patients.

摘要

背景与目的

创伤性脑损伤(TBI)是一种外力(通常是头部遭受暴力打击)导致大脑功能受损的病症。神经调节技术被认为可恢复大脑中改变的功能,从而改善功能并减轻症状。脑刺激可改变神经元的放电、增强突触强度、改变神经递质和兴奋性毒性,并改变神经网络中的连接。所有这些都是对大脑活动的潜在影响。因此,这是一种有前景的TBI治疗方法。这些技术具有灵活性,因为它们可以针对不同的脑区,并且在频率和幅度上有所不同。本综述旨在研究有关用于TBI患者康复的神经调节技术的最新文献。

材料与方法

通过在PubMed、科学网、考克兰、Embase和Scopus数据库上进行在线搜索来确定研究。选取了2013年至2023年间发表的研究。本综述已在开放科学框架(OSF)上注册(JEP3S)。

结果

我们发现神经调节技术可通过多种方式改善TBI患者的康复进程。经颅磁刺激(TMS)可改善认知功能,如记忆能力、神经基质,并总体提高神经心理测试的表现。重复经颅磁刺激有可能增加许多TBI患者的神经连接,但并非所有患者都如此,例如患有慢性弥漫性轴索损伤的患者。

结论

本综述表明神经调节技术在康复领域是有前景的工具手段,包括对TBI患者。神经调节的功效可对他们的生活产生重大影响,并改善TBI患者的功能结局。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6253/10886871/204781020f38/biomedicines-12-00438-g001.jpg

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