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探讨靶向背侧前扣带回皮层的阳极和阴极高清经颅直流电刺激的影响。

Exploring the effects of anodal and cathodal high definition transcranial direct current stimulation targeting the dorsal anterior cingulate cortex.

机构信息

The University of Texas at Dallas, School of Behavioral and Brain Sciences, 800 West Campbell Road, Texas, 75080, USA.

出版信息

Sci Rep. 2018 Mar 13;8(1):4454. doi: 10.1038/s41598-018-22730-x.

DOI:10.1038/s41598-018-22730-x
PMID:29535340
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5849683/
Abstract

The dorsal anterior cingulate cortex (dACC) has been identified as a core region affected by many disorders, representing a promising target for neuromodulation. High Definition-transcranial Direct Current Stimulation (HD-tDCS) is a non-invasive neuromodulation technique that has already shown promising outcomes and has been tested to engage deeper structures. This study investigates whether it is possible to modulate dACC activity using anodal and cathodal HD-tDCS. Furthermore, it examines what effects anodal and cathodal HD-tDCS targeting dACC have on cognitive and emotional processing. Forty-five healthy subjects were randomly assigned to 1 of 3 groups: anodal, cathodal, and sham. Resting-state electroencephalography (rsEEG) and a cognitive and emotional Counting Stroop task were administered before and after HD-tDCS. RsEEG showed changes: anodal HD-tDCS showed significant increase in beta frequency band activity in dACC, while cathodal HD-tDCS led to significant increase in activity at dorsal and rostral ACC in the theta frequency band. Behavioral changes were also found after anodal HD-tDCS in the cognitive Counting Stroop for incongruent trials and after cathodal HD-tDCS in the emotional Counting Stroop for emotional trials. This study demonstrated that HD-tDCS is able to modulate dACC activity, suggesting that it has the potential to be used as a treatment tool.

摘要

背侧前扣带皮层（dACC）已被确定为受许多疾病影响的核心区域，是神经调节的有前途的靶点。高清晰度经颅直流电刺激（HD-tDCS）是一种非侵入性的神经调节技术，已经显示出有希望的结果，并已被测试用于涉及更深层次的结构。本研究调查使用阳极和阴极 HD-tDCS 是否可以调节 dACC 活性。此外，它还研究了针对 dACC 的阳极和阴极 HD-tDCS 对认知和情绪处理的影响。45 名健康受试者被随机分配到 3 个组之一：阳极、阴极和假刺激。在 HD-tDCS 前后进行静息态脑电图（rsEEG）和认知与情绪计数斯特鲁普任务。rsEEG 显示出变化：阳极 HD-tDCS 导致 dACC 中β频带活动显著增加，而阴极 HD-tDCS 导致θ频带中背侧和额侧 ACC 的活动显著增加。在认知计数斯特鲁普任务中，阳极 HD-tDCS 还导致不一致试验的认知变化，在情绪计数斯特鲁普任务中，阴极 HD-tDCS 导致情绪试验的情绪变化。这项研究表明，HD-tDCS 能够调节 dACC 活性，这表明它有可能被用作治疗工具。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8f9/5849683/dfbd252f4cec/41598_2018_22730_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8f9/5849683/d826e07dbc46/41598_2018_22730_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8f9/5849683/2a255934a377/41598_2018_22730_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8f9/5849683/a84d79b95c47/41598_2018_22730_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8f9/5849683/b15f430a7ff9/41598_2018_22730_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8f9/5849683/199c9efc674c/41598_2018_22730_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8f9/5849683/663eb915f7d0/41598_2018_22730_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8f9/5849683/a0c8d0d5c3b9/41598_2018_22730_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8f9/5849683/dfbd252f4cec/41598_2018_22730_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8f9/5849683/d826e07dbc46/41598_2018_22730_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8f9/5849683/2a255934a377/41598_2018_22730_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8f9/5849683/a84d79b95c47/41598_2018_22730_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8f9/5849683/b15f430a7ff9/41598_2018_22730_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8f9/5849683/199c9efc674c/41598_2018_22730_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8f9/5849683/663eb915f7d0/41598_2018_22730_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8f9/5849683/a0c8d0d5c3b9/41598_2018_22730_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8f9/5849683/dfbd252f4cec/41598_2018_22730_Fig8_HTML.jpg

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