Atallah Richard Teofilo, Castanos Maria Virginia, Najac Richard, Donnenfeld Eric
Rutgers New Jersey Medical School , Newark, NJ, USA.
Department of Research, Eye and Ear Infirmary of Mount Sinai, New York, NY, USA.
Clin Ophthalmol. 2019 Jun 19;13:1033-1037. doi: 10.2147/OPTH.S191635. eCollection 2019.
To evaluate 6-month treatment benefits with lifitegrast ophthalmic solution 5% in symptomatic dry eye patients.
Retrospective chart analysis.
A retrospective chart review was conducted in 168 patients (111 females and 57 males) who presented with symptoms of chronic dry eye disease and were treated with lifitegrast 5% ophthalmic solution for 6 months. Collected symptom data included improvement of eye dryness, tearing, eye pain, fluctuation in vision, foreign body sensation, itching, grittiness, burning and contact lens intolerance if applicable. Collected clinical signs included changes in superficial punctate keratitis, corneal fluorescein staining, conjunctival hyperemia and presence of tear debris.
Treatment with lifitegrast ophthalmic solution 5% twice daily for 6 months significantly improved majority of dry eye symptoms reported by patients. Improvements were also observed in corneal and conjunctival staining and tear debris for most of the patients reviewed.
Treatment with lifitegrast twice a day for 6 months improved both signs and symptoms of chronic dry eye.
评估5%利非司特滴眼液对有症状的干眼患者6个月的治疗效果。
回顾性病历分析。
对168例（111例女性和57例男性）患有慢性干眼疾病症状并接受5%利非司特滴眼液治疗6个月的患者进行回顾性病历审查。收集的症状数据包括眼干、流泪、眼痛、视力波动、异物感、瘙痒、沙砾感、烧灼感以及适用时的隐形眼镜不耐受情况的改善。收集的临床体征包括浅层点状角膜炎、角膜荧光素染色、结膜充血和泪液碎屑的变化。
每天两次使用5%利非司特滴眼液治疗6个月可显著改善患者报告的大多数干眼症状。在大多数接受审查的患者中，角膜和结膜染色以及泪液碎屑也有改善。
每天两次使用利非司特治疗6个月可改善慢性干眼的体征和症状。
