Tsuru N, Maeda T, Tsuruoka M
Department of Psychiatry, Miyazaki Medical College.
Jpn J Psychiatry Neurol. 1988 Mar;42(1):89-96. doi: 10.1111/j.1440-1819.1988.tb01960.x.
Here is a report of three cases of delivery from women who have taken sodium valproate (VPA). One neonate was born with polydactylism, and we reviewed the congenital malformations in children of mothers who have taken VPA. In the other two cases, we also examined the levels of VPA in the cord serum and breast milk. The levels of VPA in the cord serum were 50 micrograms/ml at 12 hours after the last maternal dose and 75 micrograms/ml at 14 hours after the last maternal dose. The blood levels of VPA in the two mothers were 48-59 micrograms/ml and 55-85 micrograms/ml in their late pregnancy, respectively. The levels of VPA in the breast milk were 2.0-3.5 micrograms/ml and the ratio of VPA in the breast milk to blood was 2-3%. These results suggest the high rate of placental transfer and the low rate of milk transfer of VPA.
以下是三例服用丙戊酸钠（VPA）的女性分娩情况报告。一名新生儿出生时患有多指畸形，我们回顾了服用VPA的母亲所生子女的先天性畸形情况。在另外两例中，我们还检测了脐血血清和母乳中VPA的水平。最后一剂母体用药后12小时，脐血血清中VPA水平为50微克/毫升，最后一剂母体用药后14小时为75微克/毫升。两名母亲在妊娠晚期血液中VPA水平分别为48 - 59微克/毫升和55 - 85微克/毫升。母乳中VPA水平为2.0 - 3.5微克/毫升，母乳中VPA与血液中VPA的比例为2 - 3%。这些结果表明VPA的胎盘转运率高而乳汁转运率低。
