Zhang Youxue, Guo Gang, Tian Yuan
School of Psychology, Chengdu Normal University, Chengdu, China.
School of Foreign Languages, Chengdu Normal University, Chengdu, China.
Front Psychiatry. 2019 Jul 12;10:484. doi: 10.3389/fpsyt.2019.00484. eCollection 2019.
Schizophrenic subject is thought as a self-disorder patient related with abnormal brain functional network. It has been hypothesized that self-disorder is associated with the deficient functional integration of multisensory body signals in schizophrenic subjects. To further verify this assumption, 53 chronic schizophrenic subjects and 67 healthy subjects were included in this study and underwent resting-state functional magnetic resonance imaging. The data-driven methods, whole-brain temporal variability of fractional amplitude of low-frequency fluctuations and regional homogeneity (ReHo), were used to investigate dynamic local functional connectivity and dynamic local functional activity changes in schizophrenic subjects. Patients with schizophrenia exhibited increased temporal variability ReHo and fractional amplitude of low-frequency fluctuations across time windows within sensory and perception network (such as occipital gyrus, precentral and postcentral gyri, superior temporal gyrus, and thalamus). Critically, the increased dynamic ReHo of thalamus is significantly correlated with positive and total symptom of schizophrenic subjects. Our findings revealed that deficit in sensory and perception functional networks might contribute to neural physiopathology of self-disorder in schizophrenic subjects.
精神分裂症患者被认为是一种与大脑功能网络异常相关的自我障碍患者。有假设认为，自我障碍与精神分裂症患者多感官身体信号的功能整合不足有关。为了进一步验证这一假设，本研究纳入了53名慢性精神分裂症患者和67名健康受试者，并对他们进行了静息态功能磁共振成像。采用数据驱动方法，即低频波动分数振幅的全脑时间变异性和局部一致性（ReHo），来研究精神分裂症患者动态局部功能连接和动态局部功能活动变化。精神分裂症患者在感觉和知觉网络（如枕叶、中央前回和中央后回、颞上回和丘脑）的时间窗内表现出ReHo和低频波动分数振幅的时间变异性增加。至关重要的是，丘脑动态ReHo的增加与精神分裂症患者的阳性症状和总症状显著相关。我们的研究结果表明，感觉和知觉功能网络的缺陷可能导致精神分裂症患者自我障碍的神经生理病理学。
