Wang Yingchan, Jiang Yuchao, Liu Dengtang, Zhang Jianye, Yao Dezhong, Luo Cheng, Wang Jijun
Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, Center for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
Psychiatry Investig. 2021 Dec;18(12):1205-1212. doi: 10.30773/pi.2020.0418. Epub 2021 Dec 23.
Abnormalities of static brain activity have been reported in schizophrenia, but it remains to be clarified the temporal variability of intrinsic brain activities in schizophrenia and how atypical antipsychotics affect it.
We employed a resting-state functional magnetic resonance imaging (rs-fMRI) and a sliding-window analysis of dynamic amplitude of low-frequency fluctuation (dALFF) to evaluate the dynamic brain activities in schizophrenia (SZ) patients before and after 8-week antipsychotic treatment. Twenty-six schizophrenia individuals and 26 matched healthy controls (HC) were included in this study.
Compared with HC, SZ showed stronger dALFF in the right inferior temporal gyrus (ITG.R) at baseline. After medication, the SZ group exhibited reduced dALFF in the right middle occipital gyrus (MOG.R) and increased dALFF in the left superior frontal gyrus (SFG.L), right middle frontal gyrus (MFG.R), and right inferior parietal lobule (IPL.R). Dynamic ALFF in IPL.R was found to significant negative correlate with the Scale for the Assessment of Negative Symptoms (SANS) scores at baseline.
Our results showed dynamic intrinsic brain activities altered in schizophrenia after short term antipsychotic treatment. The findings of this study support and expand the application of dALFF method in the study of the pathological mechanism in psychosis in the future.
已有报道称精神分裂症患者存在静息脑活动异常，但精神分裂症患者内在脑活动的时间变异性以及非典型抗精神病药物如何影响这种变异性仍有待阐明。
我们采用静息态功能磁共振成像（rs-fMRI）和低频波动动态幅度的滑动窗口分析（dALFF）来评估8周抗精神病药物治疗前后精神分裂症（SZ）患者的动态脑活动。本研究纳入了26名精神分裂症患者和26名匹配的健康对照（HC）。
与HC相比，SZ在基线时右侧颞下回（ITG.R）的dALFF更强。用药后，SZ组右侧枕中回（MOG.R）的dALFF降低，左侧额上回（SFG.L）、右侧额中回（MFG.R）和右侧顶下小叶（IPL.R）的dALFF增加。发现IPL.R的动态ALFF与基线时的阴性症状评定量表（SANS）评分显著负相关。
我们的结果显示，短期抗精神病药物治疗后精神分裂症患者的动态内在脑活动发生了改变。本研究结果支持并扩展了dALFF方法在未来精神病病理机制研究中的应用。
