Rivera-Soto Ricardo, Damania Blossom
Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Curriculum in Genetics and Molecular Biology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Front Microbiol. 2019 Jul 12;10:1544. doi: 10.3389/fmicb.2019.01544. eCollection 2019.
Angiogenesis is the biological process by which new blood vessels are formed from pre-existing vessels. It is considered one of the classic hallmarks of cancer, as pathological angiogenesis provides oxygen and essential nutrients to growing tumors. Two of the seven known human oncoviruses, Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV), belong to the subfamily. Both viruses are associated with several malignancies including lymphomas, nasopharyngeal carcinomas, and Kaposi's sarcoma. The viral genomes code for a plethora of viral factors, including proteins and non-coding RNAs, some of which have been shown to deregulate angiogenic pathways and promote tumor growth. In this review, we discuss the ability of both viruses to modulate the pro-angiogenic process.
血管生成是指从已有的血管中形成新血管的生物学过程。它被认为是癌症的经典特征之一，因为病理性血管生成为生长中的肿瘤提供氧气和必需营养物质。已知的七种人类致癌病毒中的两种，即爱泼斯坦-巴尔病毒（EBV）和卡波西肉瘤相关疱疹病毒（KSHV），属于该亚科。这两种病毒都与多种恶性肿瘤有关，包括淋巴瘤、鼻咽癌和卡波西肉瘤。病毒基因组编码大量病毒因子，包括蛋白质和非编码RNA，其中一些已被证明会破坏血管生成途径并促进肿瘤生长。在本综述中，我们讨论了这两种病毒调节促血管生成过程的能力。
