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本文引用的文献

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Prognostic Role of Pretreatment Plasma D-Dimer in Patients with Solid Tumors: a Systematic Review and Meta-Analysis.治疗前血浆D-二聚体在实体瘤患者中的预后作用：一项系统评价和Meta分析
Cell Physiol Biochem. 2018;45(4):1663-1676. doi: 10.1159/000487734. Epub 2018 Feb 22.
2
CEA but not CA19-9 is an independent prognostic factor in patients undergoing resection of cholangiocarcinoma.CEA 而非 CA19-9 是接受胆管癌切除术患者的独立预后因素。
Sci Rep. 2017 Dec 5;7(1):16975. doi: 10.1038/s41598-017-17175-7.
3
A New Preoperative Prognostic System Combining CRP and CA199 For Patients with Intrahepatic Cholangiocarcinoma.一种结合CRP和CA199的肝内胆管癌患者术前预后新系统。
Clin Transl Gastroenterol. 2017 Oct 5;8(10):e118. doi: 10.1038/ctg.2017.45.
4
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J Gastroenterol Hepatol. 2018 Apr;33(4):958-965. doi: 10.1111/jgh.13966. Epub 2018 Jan 26.
5
Effects of Preoperative Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios on Survival in Patients with Extrahepatic Cholangiocarcinoma.术前中性粒细胞与淋巴细胞比值及血小板与淋巴细胞比值对肝外胆管癌患者生存的影响
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Research on the coagulation function changes in non small cell lung cancer patients and analysis of their correlation with metastasis and survival.非小细胞肺癌患者凝血功能变化及其与转移和生存相关性的研究
J BUON. 2017 Mar-Apr;22(2):462-467.
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Serum liver enzymes serve as prognostic factors in patients with intrahepatic cholangiocarcinoma.血清肝酶是肝内胆管癌患者的预后因素。
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Prognostic nutritional index serves as a predictive marker of survival and associates with systemic inflammatory response in metastatic intrahepatic cholangiocarcinoma.预后营养指数可作为转移性肝内胆管癌生存的预测指标，并与全身炎症反应相关。
Onco Targets Ther. 2016 Oct 19;9:6417-6423. doi: 10.2147/OTT.S112501. eCollection 2016.
10
Elevated NLR in gallbladder cancer and cholangiocarcinoma - making bad cancers even worse: results from the US Extrahepatic Biliary Malignancy Consortium.胆囊癌和胆管癌中升高的中性粒细胞与淋巴细胞比值——使恶性肿瘤雪上加霜：美国肝外胆管恶性肿瘤联盟的研究结果
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在接受手术治疗的胆管癌患者中，凝血酶原时间的临床意义。

Clinical Significance of Prothrombin Time in Cholangiocarcinoma Patients with Surgeries.

机构信息

Nanjing Medical University, 101 Longmian Avenue, Jiangning District, Nanjing 211166, Jiangsu Province, China.

Medical Center for Digestive Diseases, The Second Affiliated Hospital of Nanjing Medical University, 121 Jiangjiayuan, Nanjing 210011, Jiangsu Province, China.

出版信息

Can J Gastroenterol Hepatol. 2019 Jul 1;2019:3413969. doi: 10.1155/2019/3413969. eCollection 2019.

DOI:10.1155/2019/3413969
PMID:31355160
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6634076/
Abstract

BACKGROUND

Prothrombin time (PT) can predict survival in several types of malignancies. This study aims to investigate the predictive values of PT levels in patients with cholangiocarcinoma (CCA).

METHODS

We retrospectively analyzed the PT from 86 CCA patients who underwent curative resection in our hospital from December 2008 to August 2017. The relationship between PT and survival times was analyzed through univariate and multivariate analyses (Cox proportional hazards model). Kaplan-Meier curves and log-rank test were used to assess the effects of PT on overall survival (OS) and tumor recurrence-free survival (RFS).

RESULTS

Increased PT level was an effective predictor for OS (P = 0.021; hazard ratio (HR), 1.799) and RFS (P = 0.016; HR, 1.871) in CCA patients, independent of age, tumor differentiation, and TNM stage. In the low PT level group (PT < 12.3 s), patients showed a higher mean OS (23.03 m vs. 14.38 m, P = 0.0250) and RFS (17.78 m vs. 8.30 m, P = 0.0511) than those with high PT levels (PT ≥ 12.3 s). A highly significant association was observed between high PT level and shortened OS (P = 0.0373) and worse RFS (P = 0.0151).

CONCLUSION

Preoperative increase in PT can serve as a simple but effective predictor of poor survival in CCA patients who undergo curative surgeries.

摘要

背景

凝血酶原时间（PT）可预测多种恶性肿瘤的生存情况。本研究旨在探讨 PT 水平在胆管癌（CCA）患者中的预测价值。

方法

我们回顾性分析了 2008 年 12 月至 2017 年 8 月在我院接受根治性切除术的 86 例 CCA 患者的 PT。通过单因素和多因素分析（Cox 比例风险模型）分析 PT 与生存时间的关系。Kaplan-Meier 曲线和对数秩检验用于评估 PT 对总生存（OS）和肿瘤无复发生存（RFS）的影响。

结果

PT 水平升高是 CCA 患者 OS（P = 0.021；风险比（HR），1.799）和 RFS（P = 0.016；HR，1.871）的有效预测因子，独立于年龄、肿瘤分化和 TNM 分期。在低 PT 水平组（PT < 12.3 s）中，患者的 OS（23.03 m 比 14.38 m，P = 0.0250）和 RFS（17.78 m 比 8.30 m，P = 0.0511）均高于高 PT 水平组（PT ≥ 12.3 s）。高 PT 水平与缩短 OS（P = 0.0373）和较差的 RFS（P = 0.0151）之间存在显著相关性。

结论

术前 PT 升高可作为接受根治性手术的 CCA 患者生存不良的简单而有效的预测指标。