Molecular Engineering and Sciences Institute, University of Washington, Seattle, WA, USA.
Soft Matter. 2019 Sep 25;15(37):7360-7368. doi: 10.1039/c9sm00426b.
Dynamic and environmentally directed assembly of molecules in biological systems is essential for the fabrication of micronscale, hierarchical, functional structures. Here, we demonstrate the directed assembly of genetically selected graphite binding peptides on 2D solid surfaces upon thermal stimuli. Structural and kinetic analyses as well as molecular dynamics simulations yield the self-assembly process as thermally controllable upon tuning the solvated peptide conformational states. The ability to tailor the structure of two-dimensional soft bio/nano interfaces via external stimuli shows the potential for the bottom-up fabrication of complex materials with nanotechnological importance, such as biosensors, bioelectronics, and biomolecular fuel cells.
在生物系统中，分子的动态和环境导向组装对于制造微米级、多层次、功能性结构至关重要。在这里，我们展示了在热刺激下，通过基因选择的石墨结合肽在 2D 固体表面上的定向组装。结构和动力学分析以及分子动力学模拟表明，通过调整溶剂化肽构象状态，自组装过程是可以热控的。通过外部刺激来定制二维软生物/纳米界面结构的能力显示了具有纳米技术重要性的复杂材料的自下而上制造的潜力，例如生物传感器、生物电子学和生物分子燃料电池。
