Kirchofer Kevin S, Block Gary, Johnson Justine A
J Am Vet Med Assoc. 2019 Aug 15;255(4):459-465. doi: 10.2460/javma.255.4.459.
To evaluate the efficacy of IV administration of apomorphine for removal of gastric foreign bodies in dogs.
495 dogs with gastric foreign bodies.
Records of a veterinary hospital were searched to identify dogs that received an injectable formulation of apomorphine between January 1, 2010, and July 30, 2015. Dogs with a gastric foreign body that received an IV injection of apomorphine were included in the study. Information extracted from the record of each dog included signalment, type of foreign material ingested, duration between foreign material ingestion and emesis, dose and number of doses of apomorphine administered, and whether emesis occurred and did or did not result in successful removal of the foreign body. Descriptive data were compared between dogs with and without successful foreign body removal.
Emesis with successful foreign body removal was achieved in 363 and 11 dogs after administration of 1 and 2 doses of apomorphine, respectively. Successful removal was more likely for young dogs and dogs that had ingested fabric, leather, or bathroom waste. Successful removal was less likely as the duration between foreign body ingestion and emesis increased and for dogs that received opioids, sedatives, or antiemetics before apomorphine administration. Minor adverse effects were recorded for only 4 dogs.
IV administration of apomorphine was a viable alternative for induction of emesis and removal of gastric foreign bodies in dogs. Dogs should be examined as soon as possible after foreign body ingestion and should not receive any medications that might affect apomorphine efficacy.
评估静脉注射阿扑吗啡清除犬胃内异物的疗效。
495只患有胃内异物的犬。
检索一家兽医医院的记录,以确定在2010年1月1日至2015年7月30日期间接受注射用阿扑吗啡的犬。纳入接受静脉注射阿扑吗啡且患有胃内异物的犬进行研究。从每只犬的记录中提取的信息包括特征、摄入的异物类型、异物摄入至呕吐的时长、阿扑吗啡的给药剂量和给药次数,以及是否发生呕吐且呕吐是否成功清除异物。比较异物清除成功和未成功的犬的描述性数据。
分别给予1剂和2剂阿扑吗啡后,363只和11只犬呕吐且异物清除成功。幼犬以及摄入织物、皮革或浴室废弃物的犬更有可能成功清除异物。随着异物摄入至呕吐的时长增加,以及在给予阿扑吗啡前接受过阿片类药物、镇静剂或止吐药的犬,成功清除异物的可能性较小。仅4只犬记录到轻微不良反应。
静脉注射阿扑吗啡是诱导犬呕吐和清除胃内异物的可行替代方法。犬在摄入异物后应尽快接受检查,且不应接受任何可能影响阿扑吗啡疗效的药物。