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在短头型、中头型和长头型犬中,使用阿扑吗啡诱发呕吐时,不良反应最小。

Minimal adverse events occur when inducing emesis with apomorphine in brachycephalic, mesocephalic, and dolichocephalic dogs.

机构信息

1School of Veterinary Science, University of Sydney, Camperdown, NSW, Australia.

2Animal Referral and Emergency Centre, Broadmeadow, NSW, Australia.

出版信息

J Am Vet Med Assoc. 2023 Nov 10;262(3):1-5. doi: 10.2460/javma.23.08.0472. Print 2024 Mar 1.

DOI:10.2460/javma.23.08.0472
PMID:37948848
Abstract

OBJECTIVE

To determine risks of complications with emesis induction and whether facial conformation is associated with the frequency of complications.

ANIMALS

1,788 client-owned dogs that presented immediately or by referral from a primary care veterinarian following ingestion of toxic or foreign materials.

METHODS

Patients with emesis induced with apomorphine for removal of toxic or foreign materials were retrospectively identified. Collected data included patient factors, routes of apomorphine administration, other therapies, adverse events, and patient outcomes.

RESULTS

2 types of complications were identified in a very small number of patients (11 [0.6%]), with 3 (0.17%) having regurgitation postemesis and 8 (0.44%) having prolonged vomiting. No significant difference was found in the rates of repeated vomiting or regurgitation between brachycephalic dogs and nonbrachycephalic dogs (P = .375 and P = 1.00, respectively). Brachycephalic dogs had 1.6 times greater odds of having emesis induction due to toxin ingestion compared to foreign material ingestion. The presence of clinical signs of toxicity at the time of emesis induction was associated with regurgitation (P < .001), and the development of regurgitation was associated with admission to hospital (P = .001).

CLINICAL RELEVANCE

This study found no increased risk of complications when emesis was induced using apomorphine in brachycephalic breeds compared to nonbrachycephalic breeds, regardless of indication for emesis induction. Facial conformation is not a reason to withhold emesis induction.

摘要

目的

确定催吐诱导并发症的风险,以及面部形态是否与并发症的发生频率有关。

动物

1788 只因摄入有毒或异物而出现呕吐的客户所有犬,这些犬立即或由初级保健兽医转介后接受阿扑吗啡催吐治疗。

方法

回顾性确定接受阿扑吗啡诱导呕吐以清除有毒或异物的患者。收集的数据包括患者因素、阿扑吗啡给药途径、其他治疗、不良事件和患者结局。

结果

在极少数患者(11 例[0.6%])中发现了 2 种类型的并发症,其中 3 例(0.17%)呕吐后出现反流,8 例(0.44%)出现呕吐延长。短头犬和非短头犬之间重复呕吐或反流的发生率无显著差异(P =.375 和 P = 1.00)。与因异物摄入相比,短头犬因毒素摄入而进行催吐的可能性高 1.6 倍。在进行催吐诱导时出现毒性临床症状与反流有关(P <.001),并且发生反流与住院有关(P =.001)。

临床相关性

本研究发现,与非短头犬相比,短头犬使用阿扑吗啡进行催吐时,并发症风险没有增加,无论催吐的指征如何。面部形态不是拒绝进行催吐的理由。

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