Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Department of Paediatric Dentistry, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
J Oral Pathol Med. 2019 Nov;48(10):935-942. doi: 10.1111/jop.12940. Epub 2019 Sep 17.
The aim of the present study was to report the clinicopathologic, radiographic and immunohistochemical features of five South American cases of intraosseous xanthomas of the mandible and to compare them to those detected in a literature review.
Clinical data were collected from the records of three Oral and Maxillofacial Pathology services in South America and compared with those compiled from a literature review based on a search of three electronic databases (PubMed, Web of Science and Scopus). All cases were evaluated by haematoxylin and eosin staining and immunohistochemistry for CD68 and S-100.
The series comprised four females (80%) and one male (20%) with a mean age of 23.3 ± 10.9 years (range: 13-45 years). In four cases, there was involvement of the posterior region of the mandible (80%). The lesions presented radiographically as unilocular (60%) radiolucencies with punched-out margin (80%). All cases predominantly consisted of CD68-positive and S-100-negative xanthomatous cells. No recurrences were observed after curettage, with a median follow-up of 27 months.
Intraosseous xanthoma of the jaws is a rare benign disorder. We report here five additional cases affecting the mandible, for a total of 36 cases of the jaws reported in the literature. Overall, this lesion has predilection for posterior sites of the mandible of asymptomatic young adults.
本研究旨在报告 5 例发生于下颌骨的骨内黄色瘤的临床病理、影像学和免疫组织化学特征，并与文献复习中发现的特征进行比较。
从南美洲 3 个口腔颌面病理服务机构的记录中收集临床数据，并与基于 3 个电子数据库（PubMed、Web of Science 和 Scopus）检索的文献复习中汇编的数据进行比较。所有病例均行苏木精和伊红染色，并进行 CD68 和 S-100 的免疫组织化学染色。
该系列包括 4 名女性（80%）和 1 名男性（20%），平均年龄为 23.3±10.9 岁（范围：13-45 岁）。4 例下颌骨后区受累（80%）。影像学表现为单房（60%）透亮影，边缘呈凿孔状（80%）。所有病例主要由 CD68 阳性和 S-100 阴性的黄色瘤细胞组成。刮除术后无复发，中位随访时间为 27 个月。
颌骨内黄色瘤是一种罕见的良性疾病。我们在此报告另外 5 例下颌骨受累病例，总计文献报道 36 例颌骨内黄色瘤。总体而言，该病变好发于无症状年轻成人的下颌骨后区。
