Guyotat D, Coiffier B, Campos L, Archimbaud E, Treille D, Ehrsam A, Fiere D
Bone Marrow Transplant Unit, Edouard Herriot Hospital, Lyon, France.
Acta Haematol. 1988;80(1):52-3. doi: 10.1159/000205598.
A case of acute leukaemia following intensive chemo- and radiotherapy for solid tumour is reported. A 15-year-old girl received four courses of chemotherapy with adriamycin, cyclophosphamide and cisplatinum after the surgical diagnosis of ovarian immature teratoma. An intensification treatment was performed with cyclophosphamide and total body irradiation, followed by marrow rescue. The diagnosis of myelomonocytic acute leukaemia was performed 8 months later. The patient died after a transient improvement following a treatment by hydroxyurea. The roles of the primary tumour, of the chemotherapy and of the marrow transplantation in the occurrence of leukaemia are discussed.
报告了一例实体瘤经强化化疗和放疗后发生急性白血病的病例。一名15岁女孩在手术诊断为卵巢未成熟畸胎瘤后接受了四个疗程的阿霉素、环磷酰胺和顺铂化疗。采用环磷酰胺和全身照射进行强化治疗，随后进行骨髓挽救。8个月后诊断为骨髓单核细胞性急性白血病。患者在接受羟基脲治疗后短暂好转，最终死亡。文中讨论了原发性肿瘤、化疗及骨髓移植在白血病发生中的作用。
