Werbel William A, Baroncelli Riccardo, Shoham Shmuel, Zhang Sean X
Division of Infectious Diseases, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Instituto Hispano-Luso de Investigaciones Agrarias (CIALE), University of Salamanca, Salamanca, Spain.
Transpl Infect Dis. 2019 Oct;21(5):e13153. doi: 10.1111/tid.13153. Epub 2019 Aug 13.
Colletotrichum is an important fungal plant pathogen, yet an uncommon cause of human disease. Herein we report a case of invasive, cutaneous infection in a stem cell transplant recipient due to Colletotrichum species, with accompanying review of the literature. The infection was successfully treated with a combination of liposomal amphotericin B and voriconazole. Multilocus phylogenetic analysis revealed that the distinct isolate belongs to Colletotrichum siamense, a member of the Colletotrichum gloeosporioides species complex not previously described as a human pathogen. Colletotrichum infection remains in the differential for skin lesions in the immune compromised host.
炭疽菌是一种重要的真菌植物病原体，但却是人类疾病的罕见病因。在此，我们报告一例干细胞移植受者因炭疽菌属物种引起的侵袭性皮肤感染病例，并对相关文献进行综述。该感染通过脂质体两性霉素B和伏立康唑联合治疗成功治愈。多位点系统发育分析显示，该独特菌株属于暹罗炭疽菌，它是炭疽菌盘长孢菌复合种的成员，此前未被描述为人类病原体。炭疽菌感染仍在免疫功能低下宿主皮肤病变的鉴别诊断范围内。
