Ponce Alex T, Hong Ka Lok
Department of Pharmaceutical Sciences, Nesbitt School of Pharmacy, Wilkes University, 84 W. South Street, Wilkes-Barre, PA 18766, USA.
Biomedicines. 2019 Jul 26;7(3):55. doi: 10.3390/biomedicines7030055.
The unique opportunity for aptamer uses in thrombotic events has sparked a considerable amount of research in the area. The short half-lives of unmodified aptamers in vivo remain one of the major challenges in therapeutic aptamers. Much of the incremental successful therapeutic aptamer stories were due to modifications in the aptamer bases. This mini-review briefly summarizes the successes and challenges in the clinical development of aptamers for thrombotic events, and highlights some of the most recent developments in using aptamers for anticoagulation monitoring.
适体在血栓形成事件中应用的独特机遇引发了该领域大量的研究。未修饰的适体在体内的短半衰期仍是治疗性适体的主要挑战之一。治疗性适体取得的诸多渐进式成功案例都归因于适体碱基的修饰。本综述简要总结了适体用于血栓形成事件临床开发中的成功与挑战，并重点介绍了适体用于抗凝监测的一些最新进展。
