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用于风湿性疾病相关蛋白质的适配体：诊断与治疗应用的进展、挑战及前景

Aptamers for Proteins Associated with Rheumatic Diseases: Progress, Challenges, and Prospects of Diagnostic and Therapeutic Applications.

作者信息

Shatunova Elizaveta A, Korolev Maksim A, Omelchenko Vitaly O, Kurochkina Yuliya D, Davydova Anna S, Venyaminova Alya G, Vorobyeva Mariya A

机构信息

Institute of Chemical Biology and Fundamental Medicine, Siberian Division of Russian Academy of Sciences, 630090 Novosibirsk, Russia.

Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, 630060 Novosibirsk, Russia.

出版信息

Biomedicines. 2020 Nov 22;8(11):527. doi: 10.3390/biomedicines8110527.

DOI:10.3390/biomedicines8110527
PMID:33266394
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7700471/
Abstract

Nucleic acid aptamers capable of affine and specific binding to their molecular targets have now established themselves as a very promising alternative to monoclonal antibodies for diagnostic and therapeutic applications. Although the main focus in aptamers' research and development for biomedicine is made on cardiovascular, infectious, and malignant diseases, the use of aptamers as therapeutic or diagnostic tools in the context of rheumatic diseases is no less important. In this review, we consider the main features of aptamers that make them valuable molecular tools for rheumatologists, and summarize the studies on the selection and application of aptamers for protein biomarkers associated with rheumatic diseases. We discuss the progress in the development of aptamer-based diagnostic assays and targeted therapeutics for rheumatic disorders, future prospects in the field, and issues that have yet to be addressed.

摘要

能够与其分子靶点进行亲和性和特异性结合的核酸适配体，现已成为用于诊断和治疗应用的单克隆抗体的一种非常有前景的替代物。尽管适配体在生物医学研发中的主要重点集中在心血管疾病、传染病和恶性疾病上，但在风湿病背景下将适配体用作治疗或诊断工具同样重要。在本综述中，我们探讨了适配体使其成为风湿病学家有价值的分子工具的主要特征，并总结了与风湿病相关的蛋白质生物标志物适配体的筛选和应用研究。我们讨论了基于适配体的风湿病诊断检测和靶向治疗的进展、该领域的未来前景以及尚未解决的问题。

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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52d6/7700471/97a3ec3a9bd6/biomedicines-08-00527-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52d6/7700471/33281917064a/biomedicines-08-00527-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52d6/7700471/e79ae1223c72/biomedicines-08-00527-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52d6/7700471/231dfc70a480/biomedicines-08-00527-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52d6/7700471/b552533382d0/biomedicines-08-00527-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52d6/7700471/ad8a2fa520ba/biomedicines-08-00527-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52d6/7700471/8ba600fd4442/biomedicines-08-00527-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52d6/7700471/2a4c94b02a9c/biomedicines-08-00527-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52d6/7700471/e2dbc1baca05/biomedicines-08-00527-g012.jpg

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