[细胞外囊泡在肝纤维化中的研究进展]

[Research progress of extracellular vesicles in hepatic fibrosis].

作者信息

Tao C Y, Guo J S, Shi Y H

机构信息

Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital Affiliated Fudan University, Shanghai 200032, China.

Division of Digestive Diseases, Zhongshan Hospital, Shanghai Institute of Liver Diseases, Fudan University, Shanghai 200032, China.

出版信息

Zhonghua Gan Zang Bing Za Zhi. 2019 Jun 20;27(6):407-410. doi: 10.3760/cma.j.issn.1007-3418.2019.06.003.

DOI:10.3760/cma.j.issn.1007-3418.2019.06.003

PMID:31357753

Abstract

Liver fibrosis is a pathophysiological process characterized by abnormal accumulation of connective tissues in the liver caused by chronic liver injuries, in which the activation and migration of hepatic stellate cells (HSCs) play a central role. Extracellular vesicles (EVs) are a class of nanoscale, bilayer lipid enveloped vesicles secreted by almost all cells. EVs are of great interest in liver pathology because they have been found to mediate the communication between cells and regulate cellular microenvironment via horizontal transfer of their cargoes. EVs carry bioactive cargoes including proteins, lipids and RNA molecules, and are involved in the activation of HSCs during liver fibrogenesis.

摘要

肝纤维化是一种病理生理过程，其特征是慢性肝损伤导致肝脏中结缔组织异常积聚，其中肝星状细胞（HSCs）的激活和迁移起核心作用。细胞外囊泡（EVs）是一类由几乎所有细胞分泌的纳米级双层脂质包膜囊泡。EVs在肝脏病理学中备受关注，因为它们已被发现可介导细胞间通讯，并通过其携带物质的水平转移来调节细胞微环境。EVs携带包括蛋白质、脂质和RNA分子在内的生物活性物质，并参与肝纤维化形成过程中肝星状细胞的激活。