Maderazo E G, Woronick C L, Quercia R A, Hickingbotham N, Drezner A D
Department of Medicine, Hartford Hospital, CT 06115.
Ann Surg. 1988 Aug;208(2):221-6. doi: 10.1097/00000658-198808000-00015.
Twenty patients were investigated to determine whether total parenteral nutrition (TPN) influences the recovery of neutrophil (PMN) locomotory dysfunction in blunt trauma. Half were given TPN consisting of amino acids, glucose, electrolytes, and trace minerals, and half were given intravenous (I.V.) fluids consisting of 5% glucose in water or saline, electrolytes, and trace minerals. PMN locomotion was assayed using micropore filters. Analysis of the data by general linear modeling showed that PMN locomotion in TPN patients was significantly slower during the first 3 to 4 days postinjury. By sequential analysis, improved PMN function in the group not given TPN (NO TPN) occurred less than 95% of the time. TPN with amino acids and glucose may worsen and delay the recovery of PMN locomotory responses in blunt trauma, but the preference ratio of NO TPN:TPN for better PMN function was less than 95:5.
对20名患者进行了调查，以确定全胃肠外营养（TPN）是否会影响钝性创伤中中性粒细胞（PMN）运动功能障碍的恢复。其中一半患者接受由氨基酸、葡萄糖、电解质和微量矿物质组成的TPN，另一半患者接受由5%葡萄糖水溶液或生理盐水、电解质和微量矿物质组成的静脉输液。使用微孔滤膜测定PMN运动。通过一般线性模型对数据进行分析表明，在受伤后的前3至4天，接受TPN治疗的患者的PMN运动明显较慢。通过序贯分析，未接受TPN（无TPN）组中PMN功能改善的发生率低于95%。含氨基酸和葡萄糖的TPN可能会使钝性创伤中PMN运动反应的恢复恶化并延迟，但无TPN组与TPN组PMN功能改善的优势比小于95:5。
