腐胺，大鼠肾上腺中γ-氨基丁酸的一个来源。
Putrescine, a source of gamma-aminobutyric acid in the adrenal gland of the rat.
作者信息
Caron P C, Cote L J, Kremzner L T
机构信息
Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, NY 10032.
出版信息
Biochem J. 1988 Apr 15;251(2):559-62. doi: 10.1042/bj2510559.
Putrescine is the major source of gamma-aminobutyric acid (GABA) in the rat adrenal gland. Diamine oxidase, and not monoamine oxidase, is essential for GABA formation from putrescine in the adrenal gland. Aminoguanidine, a diamine oxidase inhibitor, decreases the GABA concentration in the adrenal gland by more than 70% after 4 h, and almost to zero in 24 h. Studies using [14C]putrescine confirm that [14C]GABA is the major metabolite of putrescine in the adrenal gland. Inhibition of GABA transaminase by amino-oxyacetic acid does not change the GABA concentration in the adrenal gland, as compared with the brain, where the GABA concentration rises. With aminoguanidine, the turnover time of GABA originating from putrescine in the adrenal gland is 5.6 h, reflecting a slower rate of GABA metabolism compared with the brain. Since GABA in the adrenal gland is almost exclusively derived from putrescine, the role of GABA may relate to the role of putrescine as a growth factor and regulator of cell metabolism.
腐胺是大鼠肾上腺中γ-氨基丁酸（GABA）的主要来源。二胺氧化酶而非单胺氧化酶对于肾上腺中由腐胺形成GABA至关重要。二胺氧化酶抑制剂氨基胍在4小时后可使肾上腺中GABA浓度降低70%以上，24小时后几乎降至零。使用[14C]腐胺的研究证实，[14C]GABA是肾上腺中腐胺的主要代谢产物。与大脑中GABA浓度升高不同，氨基氧乙酸抑制GABA转氨酶并不会改变肾上腺中GABA的浓度。使用氨基胍时，肾上腺中源自腐胺的GABA周转时间为5.6小时，这表明与大脑相比，GABA的代谢速率较慢。由于肾上腺中的GABA几乎完全源自腐胺，GABA的作用可能与腐胺作为生长因子和细胞代谢调节剂的作用有关。
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