Fiseha Temesgen, Mengesha Tizita, Girma Rahel, Kebede Edosa, Gebreweld Angesom
Department of Clinical Laboratory Science, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia.
BMC Res Notes. 2019 Jul 29;12(1):462. doi: 10.1186/s13104-019-4487-6.
The aim of this study was to estimate the prevalence of renal insufficiency using estimated glomerular filtration rate (eGFR) among adult outpatients with normal SCr.
A total of 414 patients with normal SCr were included in the study. Mean GFR (ml/min/1.73 m) was 116.8 ± 43.5 using the MDRD equation and 90.5 ± 33.1 by the C-G formula. According to the MDRD formula, mild renal insufficiency (i.e. eGFR 60-89.9 ml/min/1.73 m) was found in 21.5% of the patients and moderate renal insufficiency (i.e. eGFR 30-59.9 ml/min/1.73 m) was found in 7.7%. According to the Cockcroft-Gault (C-G) formula, mild renal insufficiency was found in 38.2% and moderate renal insufficiency in 16.9% of the patients with normal SCr. In multivariate analysis, older age, female sex, a family history of kidney disease or other chronic diseases and high systolic blood pressure were associated with prevalent renal insufficiency depending on the formula used to estimate GFR. This study demonstrates the substantial prevalence of impaired renal function among Ethiopian adult outpatients with normal SCr. Including calculated estimates of GFR in routine laboratory reporting may help to facilitate the identification and thus optimal management of patients with renal insufficiency.
本研究旨在使用估算肾小球滤过率（eGFR）评估血清肌酐（SCr）正常的成年门诊患者中肾功能不全的患病率。
本研究共纳入414例SCr正常的患者。使用MDRD方程计算的平均肾小球滤过率（ml/min/1.73m²）为116.8±43.5，使用C-G公式计算的为90.5±33.1。根据MDRD公式，21.5%的患者存在轻度肾功能不全（即eGFR 60 - 89.9ml/min/1.73m²），7.7%的患者存在中度肾功能不全（即eGFR 30 - 59.9ml/min/1.73m²）。根据Cockcroft-Gault（C-G）公式，SCr正常的患者中38.2%存在轻度肾功能不全，16.9%存在中度肾功能不全。在多变量分析中，根据用于估算肾小球滤过率的公式不同，年龄较大、女性、有肾脏疾病或其他慢性疾病家族史以及收缩压较高与普遍存在的肾功能不全相关。本研究表明，在埃塞俄比亚SCr正常的成年门诊患者中，肾功能受损的患病率相当高。在常规实验室报告中纳入肾小球滤过率的计算估计值可能有助于促进肾功能不全患者的识别，从而实现最佳管理。
