HIV感染者中的严重贫血：人口统计学、临床及肾脏相关因素

Severe anaemia in people with HIV: demographic, clinical and renal correlates.

作者信息

Kamvuma Kingsley, Munsaka Sody, Masenga Sepiso K, Mulemena John Amos, Phiri Christopher Newton, Miyoba Michelo, Hamooya Benson M

机构信息

HAND Research Group, School of Medicine and Health Sciences, Department of Pathology and Microbiology, Mulungush University, Livingstone campus, Livingstone, Zambia.

Department of Biomedical Sciences, University of Zambia of Health Science and Medicine, Lusaka, Zambia.

出版信息

BMC Res Notes. 2025 Feb 3;18(1):51. doi: 10.1186/s13104-025-07100-x.

DOI:10.1186/s13104-025-07100-x

PMID:39901231

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11792207/

Abstract

OBJECTIVE

This study aimed to investigate the sociodemographic, clinical and renal correlates associated with severe anaemia among people with HIV.

METHODS

We conducted a cross-sectional analysis of people with HIV on antiretroviral therapy (ART) for at least 6 months, stratified by anaemia status. Anaemia was defined based on the World Health Organisation (WHO) classification, as haemoglobin concentration lower than normal i.e. <12 g/dl in females and < 13 g/dl in males and the primary outcome, severe anaemia, as a haemoglobin level below 8 g/dl according to the World Health Organisation.

RESULTS

The study comprised 372 participants receiving ART, of whom 236 (63.4%) were females. The mean age ± SD of the participants was 44.8 ± 12.4 years. The overall prevalence of severe anaemia was 7.8% (95% CI: 0.053-0.111). In multivariable logistic regression analysis, factors significantly associated with severe anaemia were female sex (Adjusted Odds Ratio (AOR: 14.3, 95% CI: 2.14-126.6), albumin (AOR: 0.93 95% CI: 0.88-0.98) and creatinine levels (AOR: 1.01 95% CI: 1.00-1.03).

摘要

目的

本研究旨在调查艾滋病毒感染者中与严重贫血相关的社会人口统计学、临床和肾脏方面的关联因素。

方法

我们对接受抗逆转录病毒治疗（ART）至少6个月的艾滋病毒感染者进行了横断面分析，并根据贫血状况进行分层。贫血根据世界卫生组织（WHO）的分类定义为血红蛋白浓度低于正常水平，即女性低于12 g/dl，男性低于13 g/dl，主要结局严重贫血定义为根据世界卫生组织标准血红蛋白水平低于8 g/dl。

结果

该研究包括372名接受抗逆转录病毒治疗的参与者，其中236名（63.4%）为女性。参与者的平均年龄±标准差为44.8±12.4岁。严重贫血的总体患病率为7.8%（95%置信区间：0.053 - 0.111）。在多变量逻辑回归分析中，与严重贫血显著相关的因素为女性（调整后的优势比（AOR）：14.3，95%置信区间：2.14 - 126.6）、白蛋白（AOR：0.93，95%置信区间：0.88 - 0.98）和肌酐水平（AOR：1.01，95%置信区间：1.00 - 1.03）。