Huang Lei, Zhu Hongxia, Gu Jianxiang
Intensive Care Unit, Lianshui County People's Hospital, Huai'an, 223400, China.
Department of Gastroenterology, Lianshui County People's Hospital, Huai'an, 223400, China.
J Coll Physicians Surg Pak. 2019 Aug;29(8):785-787. doi: 10.29271/jcpsp.2019.08.785.
The objective of this study was to compare effects of octreotide and continuous hemofiltration versus continuous hemofiltration alone in the treatment of severe acute pancreatitis (SAP) complicated with acute respiratory distress syndrome (ARDS). It was an experimental study carried out from April 2016 to April 2018. A total of 86 cases of SAP complicated with ARDS were randomly divided into group A and group B, with 43 cases in each group. Group A was given continuous hemofiltration alone, and group B was given continuous hemofiltration combined with octreotide. The research findings showed that serum tumor necrosis factor (TNF-α), interleukin-1 (IL-1), IL-6, IL-8, diamine oxidase (DAO), endotoxin, D-lactic acid levels and acute physiology and chronic health evaluation (APACHE II) and systemic inflammatory response syndrome (SIRS) scores of group B were lower than those of group A (all p<0.001) after treatment. There was no significant difference in mortality between two groups after 90 days of discharge (p=0.306). Compared with continuous hemofiltration alone, treatment with continuous hemofiltration plus octreotide is higher in efficiency, but did not translate into improved mortality.
本研究的目的是比较奥曲肽联合连续性血液滤过与单纯连续性血液滤过治疗重症急性胰腺炎（SAP）合并急性呼吸窘迫综合征（ARDS）的效果。这是一项于2016年4月至2018年4月开展的实验性研究。共有86例SAP合并ARDS患者被随机分为A组和B组，每组43例。A组仅接受连续性血液滤过治疗，B组接受连续性血液滤过联合奥曲肽治疗。研究结果显示，治疗后B组的血清肿瘤坏死因子（TNF-α）、白细胞介素-1（IL-1）、IL-6、IL-8、二胺氧化酶（DAO）、内毒素、D-乳酸水平以及急性生理与慢性健康状况评分系统（APACHE II）和全身炎症反应综合征（SIRS）评分均低于A组（均p<0.001）。出院90天后两组的死亡率无显著差异（p=0.306）。与单纯连续性血液滤过相比，连续性血液滤过联合奥曲肽治疗效率更高，但并未转化为死亡率的改善。
