癌症患者心理社会因素与生物标志物的关系：文献系统综述。
The relationship between psychosocial factors and biomarkers in cancer patients: A systematic review of the literature.
机构信息
Prince of Wales Clinical School, University of New South Wales, Lowy Cancer Research Building, High St, Randwick, Sydney, Australia.
Prince of Wales Clinical School, University of New South Wales, Lowy Cancer Research Building, High St, Randwick, Sydney, Australia.
出版信息
Eur J Oncol Nurs. 2019 Aug;41:88-96. doi: 10.1016/j.ejon.2019.06.002. Epub 2019 Jun 11.
PURPOSE
This review measured the relationships between psychosocial factors and biomarkers in cancer research setting in order to summarize their relationship. It may help to clarify the roles of psychosocial factors and biomarkers in cancer treatment, provide information for developing interventions, and contribute to personalized medicine.
METHODS
A total of 4 databases were searched and 2151 articles were screened. Thirty eligible articles were captured including 2093 cancer patients with 11 different kinds of tumor.
RESULTS
Totally 10 groups of biomarkers, 7 positive and 7 negative psychosocial factors were identified. Higher scores of positive psychosocial factors and lower scores of negative psychosocial factors were associated with biomarkers indicating good clinical results. Tumor types can affect the significance of results. Interactions among psychosocial factors may influence the main effect of the targeted psychosocial factors. Biomarkers in reviewed studies were immune response-related biomarkers.
CONCLUSIONS
The identified psychosocial factors may provide information for intervention development to increase the quality of life of cancer patients during their cancer treatment and promote better clinical outcomes. When investigating the relationship between psychosocial factors and biomarkers, the tumor type and interaction among psychosocial factors should be noted.
目的
本综述旨在测量癌症研究环境中心理社会因素与生物标志物之间的关系，以总结它们之间的关系。这可能有助于阐明心理社会因素和生物标志物在癌症治疗中的作用，为干预措施的制定提供信息，并促进个体化医学的发展。
方法
共检索了 4 个数据库，筛选出 2151 篇文章。共纳入 30 篇符合条件的文章，包括 11 种不同肿瘤的 2093 例癌症患者。
结果
共确定了 10 组生物标志物和 7 种正向和 7 种负向心理社会因素。较高的正向心理社会因素评分和较低的负向心理社会因素评分与预示良好临床结果的生物标志物相关。肿瘤类型会影响结果的显著性。心理社会因素之间的相互作用可能会影响目标心理社会因素的主要效应。综述中研究的生物标志物为免疫反应相关的生物标志物。
结论
确定的心理社会因素可能为干预措施的制定提供信息，以提高癌症患者在癌症治疗期间的生活质量，并促进更好的临床结局。在研究心理社会因素与生物标志物之间的关系时，应注意肿瘤类型和心理社会因素之间的相互作用。
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