植物代谢产物6-甲氧基苯并恶唑啉酮可刺激北美松林田鼠促卵泡激素分泌增加以及生殖器官增大。

The plant metabolite, 6-methoxybenzoxazolinone, stimulates an increase in secretion of follicle-stimulating hormone and size of reproductive organs in Microtus pinetorum.

作者信息

Schadler M H, Butterstein G M, Faulkner B J, Rice S C, Weisinger L A

机构信息

Department of Biological Sciences, Union College, Schenectady, New York 12308.

出版信息

Biol Reprod. 1988 May;38(4):817-20. doi: 10.1095/biolreprod38.4.817.

DOI:10.1095/biolreprod38.4.817

PMID:3135852

Abstract

The plant metabolite, 6-methoxybenzoxazolinone (6-MBOA), occurring in leaf tissue of rapidly growing monocots, cues reproduction in some mammals. In the pine vole, Microtus pinetorum, peripubertal females respond to this nonestrogenic compound with a 40% increase in serum levels of follicle-stimulating hormone (FSH). In addition, 6-MBOA significantly increases the weight of the ovary and uterus in both peripubertal and mature voles. This study is the first to offer evidence that 6-MBOA interacts with the pituitary to stimulate reproduction in voles.

摘要

植物代谢产物6-甲氧基苯并恶唑啉酮（6-MBOA）存在于快速生长的单子叶植物的叶片组织中，可促使一些哺乳动物繁殖。在松果田鼠（Microtus pinetorum）中，青春期前的雌性对这种非雌激素化合物有反应，其促卵泡激素（FSH）血清水平会升高40%。此外，6-MBOA能显著增加青春期前和成熟田鼠的卵巢和子宫重量。本研究首次提供证据表明，6-MBOA与垂体相互作用以刺激田鼠繁殖。