Butterstein G M, Schadler M H
Department of Biological Sciences, Union College, Schenectady, New York 12308.
Biol Reprod. 1988 Sep;39(2):465-71. doi: 10.1095/biolreprod39.2.465.
6-Methoxybenzoxazolinone (6-MBOA) is a novel plant metabolite that enhances reproductive status in vertebrate consumers while it inhibits insect, fungal, and bacterial infestation of the plant. Ovaries of prepubertal rats show a dose response to increasing amounts of 6-MBOA.administered in Silastic capsule implants. Ovaries increased in size in response to capsules with 0.5-3.0 cm exposed surface area of 6-MBOA, whereas larger capsules (6 cm 6-MBOA) had no effect. Removal of the pituitary in both prepubertal and mature rats eliminated the stimulatory influence of 6-MBOA. In hypophysectomized animals treated with diethylstibestrol implants, 6-MBOA did not affect ovarian weight and no animals ovulated. Administration of follicle-stimulating hormone (FSH) increased ovarian weight and stimulated production of ova, and FSH combined with 6-MBOA resulted in larger ovaries that released more ova. 6-MBOA also enhanced ovarian growth in intact prepubertal animals treated with pregnant mare's serum gonadotropin. These results show that 6-MBOA has the ability to interact with FSH to stimulate follicular development and increase ovulation. Non-steroidal plant compounds may have a significant impact on the reproductive patterns of wild animal populations.
6-甲氧基苯并恶唑啉酮（6-MBOA）是一种新型植物代谢产物，它能提高脊椎动物消费者的繁殖能力，同时抑制植物遭受昆虫、真菌和细菌的侵害。青春期前大鼠的卵巢对通过硅橡胶胶囊植入物给予的不断增加剂量的6-MBOA呈现出剂量反应。当6-MBOA的暴露表面积为0.5 - 3.0厘米的胶囊植入时，卵巢大小会增加，而更大的胶囊（6厘米6-MBOA）则没有效果。切除青春期前和成熟大鼠的垂体消除了6-MBOA的刺激作用。在用己烯雌酚植入物处理的垂体切除动物中，6-MBOA不影响卵巢重量，且没有动物排卵。给予促卵泡激素（FSH）可增加卵巢重量并刺激卵子产生，FSH与6-MBOA联合使用会使卵巢更大且释放更多卵子。6-MBOA还能增强用孕马血清促性腺激素处理的完整青春期前动物的卵巢生长。这些结果表明，6-MBOA有能力与FSH相互作用以刺激卵泡发育并增加排卵。非甾体类植物化合物可能对野生动物种群的繁殖模式产生重大影响。
