依替米星联合达托霉素较达托霉素或依替米星单药对耐甲氧西林金黄色葡萄球菌感染大鼠骨髓炎更有效。
Exebacase in Addition to Daptomycin Is More Active than Daptomycin or Exebacase Alone in Methicillin-Resistant Staphylococcus aureus Osteomyelitis in Rats.
机构信息
Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Department of Clinical Laboratory, Xiangya Hospital of Central South University, Changsha, Hunan, China.
出版信息
Antimicrob Agents Chemother. 2019 Sep 23;63(10). doi: 10.1128/AAC.01235-19. Print 2019 Oct.
Abstract
Bacteriophage-derived lysins are being developed as anti-infective agents. In an acute osteomyelitis methicillin-resistant (MRSA) model, rats receiving no treatment or treatment with daptomycin, exebacase (CF-301), or daptomycin plus exebacase had means of 5.13, 4.09, 4.65, and 3.57 log CFU/gram of bone, respectively. All treated animals had fewer bacteria than did untreated animals ( ≤ 0.0001), with daptomycin plus exebacase being more active than daptomycin ( = 0.0042) or exebacase ( < 0.001) alone.
摘要
噬菌体衍生溶菌酶被开发为抗感染药物。在耐甲氧西林金黄色葡萄球菌（MRSA）引起的急性骨髓炎模型中，未接受治疗或接受达托霉素、依沙巴斯他（CF-301）或达托霉素联合依沙巴斯他治疗的大鼠的骨组织中 CFU/克的均值分别为 5.13、4.09、4.65 和 3.57。所有接受治疗的动物的细菌数量均少于未接受治疗的动物（≤0.0001），达托霉素联合依沙巴斯他的疗效优于达托霉素（=0.0042）或依沙巴斯他（<0.001）单独治疗。
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