Henrotte J G, Viza D, Vich J M, Gueyne J
C.N.R.S., Faculté de Pharmacie, Paris.
C R Acad Sci III. 1988;306(17):525-8.
Several reports have suggested that silicon has an activating effect on cell proliferation. In order to test this hypothesis, both peripheral human lymphocytes and LDV/7 lymphoblast cells were cultured in the presence of a compound composed of monomethylsilanetriol (silanol), a soluble organic form of silicon, and serine. This molecule stimulates peripheral lymphocyte proliferation at an optimal concentration of 10 mg of silicon per liter of culture medium; in identical conditions, it inhibits the growth of lymphoblastoïd cells (p less than 0.001). Silanol-serine also inhibits the growth of PHA stimulated lymphocytes. The effect of silicon on cell growth has a negative correlation (p less than 0.001) with the mitotic activity of cultured cells: the more intense the latter, the stronger is the inhibitory effect of silanol-serine. This would suggest a regulatory role of this compound on the cell cycle.
多项报告表明，硅对细胞增殖具有激活作用。为了验证这一假设，将人外周血淋巴细胞和LDV/7淋巴母细胞在由单甲基硅三醇（硅醇）（一种可溶的有机硅形式）和丝氨酸组成的化合物存在的情况下进行培养。该分子在每升培养基中硅的最佳浓度为10毫克时刺激外周淋巴细胞增殖；在相同条件下，它抑制淋巴母细胞样细胞的生长（p小于0.001）。硅醇-丝氨酸也抑制PHA刺激的淋巴细胞的生长。硅对细胞生长的影响与培养细胞的有丝分裂活性呈负相关（p小于0.001）：后者越强烈，硅醇-丝氨酸的抑制作用越强。这表明该化合物对细胞周期具有调节作用。
