Li Shuang, Li Rui, Zeng Yong, Meng Xian-Li, Wen Chuan-Biao, Zheng Shi-Chao
Pharmacy College,Chengdu University of Traditional Chinese Medicine Chengdu 611137,China.
Medical Information Engineering College,Chengdu University of Traditional Chinese Medicine Chengdu 611137,China.
Zhongguo Zhong Yao Za Zhi. 2019 Jun;44(12):2433-2443. doi: 10.19540/j.cnki.cjcmm.20190221.004.
Aconiti Radix is a commonly used traditional Chinese medicine( TCM) herb in clinic,with the effects in expelling wind and removing damness,warming menstruation and relieving pain. With a long medicinal history and high medicinal value,it was used for anemofrigid-damp arthralgia,arthralgia,cold hernia and anesthesia analgesia. Modern pharmacological studies have shown that Aconiti Radix has a good therapeutic effect on rheumatoid arthritis,neuropathic pain and hypertension. As a well-known toxic TCM herb,its main pharmacodynamic and toxic components are alkaloids,which can lead to neurotoxicity and cardiotoxicity while exerting anti-inflammatory,analgesic,anti-tumor and other pharmacodynamic effects. Therefore,it is often processed to reduce its toxicity or combined with Paeoniae Radix Alba and Stephaniae Tetrandrae Radix to achieve the purpose of reducing toxicity and increasing efficacy in clinic.In recent years,with the deepening of the study on the incompatibility of TCM represented by " eighteen incompatible herbs",there have been new findings about TCM incompatibility. It has been found complementary effect,rather than no obvious toxic and side effects after the combination with incompatible herbs of Aconiti Radix. To provide the basis for further study and clinical application of Aconiti Radix,this paper reviewed chemical components,pharmacological action,toxicity and compatibility of Aconiti Radix by consulting relevant literatures published in recent years at home and abroad. Meanwhile,this paper also described the relationship between chemical constituents,as well as anti-inflammatory,analgesic,anti-tumor and other pharmacological effects and toxicity.
附子是临床常用的一味中药，具有祛风除湿、温经止痛的功效。其药用历史悠久，药用价值高，用于风寒湿痹、关节疼痛、寒疝、麻醉止痛等。现代药理研究表明，附子对类风湿关节炎、神经病理性疼痛和高血压有良好的治疗作用。作为一味著名的有毒中药，其主要药效成分和毒性成分均为生物碱，在发挥抗炎、镇痛、抗肿瘤等药效作用的同时可导致神经毒性和心脏毒性。因此，临床常对其进行炮制以降低毒性，或与白芍、防己等配伍以达到减毒增效的目的。近年来，随着以“十八反”为代表的中药配伍禁忌研究的深入，关于中药配伍有了新的发现，发现附子与反药配伍后并非无明显毒副作用，而是具有互补作用。为给附子的进一步研究和临床应用提供依据，本文通过查阅近年来国内外发表的相关文献，对附子的化学成分、药理作用、毒性及配伍进行综述，同时阐述了其化学成分与抗炎、镇痛、抗肿瘤等药理作用及毒性之间的关系。
